Relcobatinib
Relcobatinib (Relcobatinibum) is a ABL1 kinase inhibitor with an IC50 of 12.7 nM against wild-type ABL1 and an IC50 of 43.5 nM against the ABL1T315I mutant. Relcobatinib inhibits the phosphorylation of CRKL. Relcobatinib exhibits anticancer activity against chronic myeloid leukemia. Relcobatinib can be used in studies related to chronic myeloid leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2767305-95-1
- 分子式: C18H12D6FN5O3
- 分子量:377.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Abl1 12.7 nM (IC50) |
Abl1T315I 43.5 nM (IC50) |
Relcobatinib (Compound 95) potently inhibits K562 cell proliferation with an IC50 of 47.8 nM and weakly inhibits HL60 cell proliferation with an IC50 of 3550 nM[1].
Relcobatinib inhibits wild-type ABL1 kinase activity with an IC50 of 12.7 nM and ABL1T315I mutant kinase activity with an IC50 of 43.5 nM in a cell-free biochemical assay[1].
Relcobatinib inhibits CRKL phosphorylation in K562 cells with an IC50 of 66.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 2767305-95-1
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非標識Cas 2767304-26-5
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分子量 377.40
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分子式 C18H12D6FN5O3
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SMILES
CN1C(C2=C(OC([2H])([2H])[2H])N=CN=C2OC([2H])([2H])[2H])=CC3=CC(NC([C@H]4[C@H](C4)F)=O)=NC=C31
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別名
Relcobatinibum
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Relcobatinib 関連分類
HY-184100S 関連分類
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