Resolvin D4
Based on 1 Customer Validation
Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.8%
- CAS 番号: 1025684-60-9
- 分子式: C22H32O5
- 分子量:376.49
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保管条件:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Resolvin D4 (RvD4) stops neutrophil infiltration in sterile peritonitis and S. aureus skin infection[1].
Resolvin D4 (RvD4, 0-10 nM) enhances human macrophage and dermal fibroblast phagocytosis and efferocytosis[1].
Resolvin D4 (RvD4, 0-10 nM) statistically significantly increases macrophage efferocytosis of apoptotic neutrophils by 40-50%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Resolvin D4 (RvD4, 10 ng/mouse) modulates the severity of thrombo-inflammatory disease in vivo and improves thrombus resolution[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8-week-old male FVB mice (a self-limited bacterial inoculation (105 c.f.u) into the dorsal pouch)[1].
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Dosage:200 ng/mouse (saline containing 0.01% EtOH).
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Administration:I.P..
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Result:Gave lower PMN levels in the cavity in mice treated with RvD4.
Significantly lowered bacterial counts when compared to vehicle control.
Stopped leukocyte influx to the site of infection in the dorsal pouch cavity as well as the inflammation-initiating eicosanoids by reducing levels of PGD2 and LTB4.
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Animal Model:Thrombus-bearing mice[2].
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Dosage:3 µg.
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Administration:IV via tail vein injection on day 1 and day 4 after IVC stenosis.
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Result:Accelerated venous thrombus resolution in mice.
化学情報
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CAS 番号 1025684-60-9
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性状 Liquid
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分子量 376.49
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分子式 C22H32O5
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Color Colorless to light yellow
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SMILES
CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCC(O)=O
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別名
RvD4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
純度とドキュメンテーション
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データシート (265 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jeremy W Winkler, et al. Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance. Sci Rep. 2016 Jan 8:6:18972. [Content Brief]
[2]. Deya Cherpokova, et al. Resolvin D4 attenuates the severity of pathological thrombosis in mice. Blood. 2019 Oct 24;134(17):1458-1468. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Resolvin D4 関連分類
HY-113533 関連分類
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