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製品番号: HY-159518

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ROS inducer 4

ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic signaling in mitochondria.

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CAS 番号: 2959444-40-5
分子式: C₄₉H₆₂BrO₄P
分子量:825.89

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ROS inducer 4 構造式

CAS 番号: 2959444-40-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

ROS inducer 4 (compound TE3) shows anticancer activity against HeLa, A549, and HCT-15 cells with IC₅₀ values of 4.83, 3.49, and 8.74 μM, respectively^[1].
ROS inducer 4 (8 µM) disrupts mitochondrial function in HeLa cells by inducing ROS^[1].
ROS inducer 4 (1-8 µM) induces cell apoptosis in HeLa cells in a dose-dependent manner^[1].
ROS inducer 4 exhibits greatly enhanced anticancer activity compared to the parent molecule Ergosterol peroxide (HY-N3845)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

The LD50 of ROS inducer 4 (compound TE3) in C57BL/6 female mice is 70 mg/kg and the 95 % confidence interval was 59.29-97.9 mg/kg^[1].
ROS inducer 4 (1-2 mg/kg) has better anti-cervical cancer activity and safety than the Cisplatin (HY-17394), and can activate the immune response in mice^[1].
ROS inducer 4 has moderate toxicity, ROS inducer 4 does not have significant toxic effects at an effective dose (1 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2959444-40-5
分子量 825.89
分子式 C₄₉H₆₂BrO₄P
SMILES

O=C(O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](/C=C/[C@H](C)C(C)C)C)CC[C@@]4([H])[C@@]3(OO5)C=C[C@@]25C1)CC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8.[Br-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liu P, et al. Mitochondrial targeted modification and anticancer mechanism of natural product ergosterol peroxide. Bioorg Chem. 2024 Jul 31;151:107688. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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