(S)-ACE-OH
Based on 1 Customer Validation
(S)-ACE‑OH is the active metabolite of Acepromazine (HY-B1506), acting as a molecular glue degrader. (S)-ACE-OH induces functional interaction between TRIM21 and NUP98, promoting protein ubiquitination and degradation of TRIM21 at the nuclear pore complex. (S)-ACE-OH triggers nucleocytoplasmic transport disorder and exerts interferon-potentiated cytotoxic effects on certain cancer cells. (S)-ACE-OH can be used in cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.17%
- 分子式: C19H24N2OS
- 分子量:328.47
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
(S)-ACE-OH (10-6-10-4 M; 3 days) reduces the viability of IFNγ-pretreated A549 and DLD-1 cells in a concentration-dependent manner, whereas its enantiomer (R)-ACE-OH shows no activity[1].
(S)-ACE-OH (2-50 μM; 8 hours) induces concentration-dependent degradation of GLE1, SMPD4 and NUP35 in IFNγ-pretreated A549 cells[1].
(S)-ACE-OH (0.5-15 μM; 30 minutes) acts as a molecular glue in vitro to induce a concentration-dependent interaction between TRIM21 (wild-type and D355A mutant) and NUP98APD[1].
(S)-ACE-OH binds directly to the TRIM21D355A PRYSPRY domain with a Kd value of 17.9 μM, and promotes the formation of a high-affinity ternary complex between TRIM21D355A and NUP98APD; it triggers TRIM21D355A-mediated polyubiquitination of polymerized NUP98APD and related proteins in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IFNγ-pretreated A549 human lung adenocarcinoma cells
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Concentration:2, 5, 10, 20, 50 μM
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Incubation Time:8 hours
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Result:Induced concentration-dependent degradation of the nuclear pore proteins GLE1, SMPD4, and NUP35.
化学情報
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性状 Oil
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分子量 328.47
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分子式 C19H24N2OS
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Color Off-white to light yellow
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SMILES
C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (304.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (287 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0444 mL | 15.2221 mL | 30.4442 mL | 76.1105 mL |
| 5 mM | 0.6089 mL | 3.0444 mL | 6.0888 mL | 15.2221 mL | |
| 10 mM | 0.3044 mL | 1.5222 mL | 3.0444 mL | 7.6110 mL | |
| 15 mM | 0.2030 mL | 1.0148 mL | 2.0296 mL | 5.0740 mL | |
| 20 mM | 0.1522 mL | 0.7611 mL | 1.5222 mL | 3.8055 mL | |
| 25 mM | 0.1218 mL | 0.6089 mL | 1.2178 mL | 3.0444 mL | |
| 30 mM | 0.1015 mL | 0.5074 mL | 1.0148 mL | 2.5370 mL | |
| 40 mM | 0.0761 mL | 0.3806 mL | 0.7611 mL | 1.9028 mL | |
| 50 mM | 0.0609 mL | 0.3044 mL | 0.6089 mL | 1.5222 mL | |
| 60 mM | 0.0507 mL | 0.2537 mL | 0.5074 mL | 1.2685 mL | |
| 80 mM | 0.0381 mL | 0.1903 mL | 0.3806 mL | 0.9514 mL | |
| 100 mM | 0.0304 mL | 0.1522 mL | 0.3044 mL | 0.7611 mL |
(S)-ACE-OH 関連分類
HY-169325 関連分類
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