SA09-Cu
SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 155641-16-0
- 分子式: C8H16CuN2O2S4
- 分子量:364.03
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 9.6 nM (NDM-1)[1]
SA09-Cu (5-160 μg/mL; 24 h) causes the survival rate of Vero E6 and L929 mouse cells higher than 60% with 40 µg/mL[1].
SA09-Cu (2, 4, 8, 16 μg/mL; 24 h) shows the obvious inhibition of NDM-1 activity in living cells (E. coli-BL21-NDM-1 and EC23) with concentration gradually increasing[1].
SA09-Cu itself demonstrates no or minor antibacterial activity (MIC≥64 μg/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 155641-16-0
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分子量 364.03
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分子式 C8H16CuN2O2S4
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SMILES
OCCN(C)C1=[S-][Cu+2]2(SC(N(C)CCO)=[S-]2)S1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SA09-Cu 関連分類
HY-150260 関連分類
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