SAK3
Based on 1 Customer Validation
SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity.
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- 純度: 99.80%
- CAS 番号: 1256269-87-0
- 分子式: C20H23N3O4
- 分子量:369.41
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
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T-type calcium channel |
SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cav3.1 or Cav3.3-overexpressing neuro2A cells
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Concentration:0.1 nM
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Incubation Time:270 s
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Result:Rapidly increased Ca2+ currents
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Animal Model:Cav3.1 knockout (KO) mice[1]
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Dosage:0.5 mg/kg
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Administration:Administered p.o.
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Result:Significantly increased ACh release in CA1, peaking at 20 min after oral administration.
化学情報
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CAS 番号 1256269-87-0
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性状 Solid
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分子量 369.41
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分子式 C20H23N3O4
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Color White to yellow
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SMILES
O=C(OCC)C1=C(C2(CC1=O)N3C=CC=C(C3=NC2=O)C)N4CCCCC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (67.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yasushi Yabuki, et al. Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology. 2017 May 1;117:1-13. [Content Brief]
[2]. Jing Xu, et al.T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model. Int J Mol Sci. 2021 Jun 8;22(12):6185. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7070 mL | 13.5351 mL | 27.0702 mL | 67.6755 mL |
| 5 mM | 0.5414 mL | 2.7070 mL | 5.4140 mL | 13.5351 mL | |
| 10 mM | 0.2707 mL | 1.3535 mL | 2.7070 mL | 6.7675 mL | |
| 15 mM | 0.1805 mL | 0.9023 mL | 1.8047 mL | 4.5117 mL | |
| 20 mM | 0.1354 mL | 0.6768 mL | 1.3535 mL | 3.3838 mL | |
| 25 mM | 0.1083 mL | 0.5414 mL | 1.0828 mL | 2.7070 mL | |
| 30 mM | 0.0902 mL | 0.4512 mL | 0.9023 mL | 2.2558 mL | |
| 40 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6919 mL | |
| 50 mM | 0.0541 mL | 0.2707 mL | 0.5414 mL | 1.3535 mL | |
| 60 mM | 0.0451 mL | 0.2256 mL | 0.4512 mL | 1.1279 mL |
SAK3 関連分類
HY-120597 関連分類
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