Salacinol
Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC50 = 3.2 μg/mL, Ki = 0.31 μg/mL), sucrase (IC50 = 0.84 μg/mL, Ki = 0.32 μg/mL), and isomaltase (IC50 = 0.59 μg/mL, Ki = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 200399-47-9
- 分子式: C9H18O9S2
- 分子量:334.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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α‑glucosidase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
0.5 μM
Compound: 12, Salacinol
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Inhibition of maltase in human Caco-2 cell membrane
Inhibition of maltase in human Caco-2 cell membrane
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[PMID: 18258441] |
Salacinol (300 mg/L; 30 min) significantly inhibits porcine pancreatic lipase activity by 12.6%[1].
Salacinol (100 mg/L; 2 h) significantly inhibits rat adipose tissue-derived lipoprotein lipase activity by 13.6%[1].
Salacinol (100 mg/L; 18 h) reduces remaining triglyceride content in rat epididymal fat-derived adipocytes to 75.3% of vehicle control[1].
Salacinol (30 min) competitively inhibits rat small intestinal brush border membrane vesicle maltase, sucrase, and isomaltase with IC50 values of 3.2, 0.84, and 0.59 μg/mL, respectively, and Ki values of 0.31, 0.32, and 0.47 μg/mL, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sucrose-induced sucrose-induced Wistar (male, weight 130-170 g)[2]
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Dosage:1.3 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
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Administration:p.o.
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Result:Significantly inhibited the increase in serum glucose.
化学情報
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CAS 番号 200399-47-9
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分子量 334.36
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分子式 C9H18O9S2
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SMILES
OC[C@@H]([C@@H](C[S@+]1[C@@H]([C@H]([C@@H](C1)O)O)CO)O)OS(=O)([O-])=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Salacinol 関連分類
HY-119741 関連分類
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- Salacinol
- 200399-47-9
- Glycosidase
- Lipase
- isomaltase
- rat small intestinal brush border membrane vesicle
- rat adipose tissue-derived lipoprotein lipase
- diabetes mellitus
- sucrase
- porcine pancreatic lipase
- Salacia reticulata
- rat intestinal maltase
- α-glucosidase
- rat epididymal fat-derived adipocytes
- Inhibitor
- inhibitor
- inhibit