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製品番号: HY-124550

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Sarcophine

(別名: (+)-Sarcophine)

Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC₅₀ value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum.

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CAS 番号: 55038-27-2
分子式: C₂₀H₂₈O₃
分子量:316.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Sarcophine 構造式

CAS 番号: 55038-27-2

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	10.38 μg/mL Compound: 6	Cytotoxicity against human A549 cells after 6 days by MTT assay Cytotoxicity against human A549 cells after 6 days by MTT assay	10.1021/np960174n
A549	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 21458279]
HCT-116	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human HCT116 cells by MTT assay Cytotoxicity against human HCT116 cells by MTT assay	[PMID: 21458279]
HL-60	IC₅₀	34.7 μM Compound: 5	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 21458279]
HT-29	ED₅₀	10.46 μg/mL Compound: 6	Cytotoxicity against human HT29 cells after 6 days by MTT assay Cytotoxicity against human HT29 cells after 6 days by MTT assay	10.1021/np960174n
KB	ED₅₀	>50 μg/mL Compound: 6	Cytotoxicity against human KB cells after 3 days by MTT assay Cytotoxicity against human KB cells after 3 days by MTT assay	10.1021/np960174n
MCF7	IC₅₀	>40 μM Compound: 5	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 21458279]
P388	ED₅₀	2.42 μg/mL Compound: 6	Cytotoxicity against mouse P388 cells after 3 days by MTT assay Cytotoxicity against mouse P388 cells after 3 days by MTT assay	10.1021/np960174n

体外実験

Sarcophine ((+)-Sarcophine) is an inhibitor of recombinant glycine receptors, with a K_i value of 2.1 μM^[1].
Sarcophine (1-100 mM; 24 h) has cytotoxicity against HEK293 cells with an LD₅₀ value of 29.3 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 55038-27-2
分子量 316.43
分子式 C₂₀H₂₈O₃
SMILES

O=C1C(C)=C2[C@](O1)([H])/C=C(C)/CC[C@H]3[C@](O3)(C)CC/C=C(C)/CC2
別名

(+)-Sarcophine
Structure Classification
- Others
Initial Source
- Marine natural products
- Other marine organisms
- Animals
Sarcophyton glaucum
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Saleh HA, et, al. Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors. Neurotoxicology. 2020 Sep;80:105-111. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
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- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Sarcophine

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Sarcophine 関連分類

HY-124550 関連分類