SB-1436
SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2925298-08-2
- 分子式: C25H21ClFNO
- 分子量:405.89
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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EeAChE 0.176 μM (IC50) |
eqBCHE 0.37 μM (IC50) |
EeAChE 0.046 μM (Ki) |
eqBCHE 0.115 μM (Ki) |
SB-1436 (Compound 7av) (1 μM, 20 min) inhibits AChE, BChE and rHuAChE with IC50s of 0.176, 0.37 and 0.08 μM, respectively[1].
SB-1436 (0.78-100 μM, 48 hours) reduces the cell viability in J774A.1 and primary astrocytes cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774A.1 cells and primary astrocytes
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Concentration:0.78-100 μM
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Incubation Time:48 hours
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Result:Reduced the cell viability in J774A.1 and primary astrocytes cell lines, and its GI50 in both cell types is ∼6.25 μM.
化学情報
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CAS 番号 2925298-08-2
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分子量 405.89
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分子式 C25H21ClFNO
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SMILES
COC1=CC2=C(C=C(/C=C/C3=CC=[N+](CC4=CC=C(F)C=C4)C=C3)C=C2)C=C1.[Cl-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SB-1436 関連分類
HY-149300 関連分類
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