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製品番号: HY-182379

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SBI-0802767

SBI-0802767 is an orally active, uncompetitive and highly selective inhibitor of protein tyrosine phosphatase (LMPTP) with an IC₅₀ of 0.239 μM. SBI-0802767 exhibits >1000-fold selectivity over other protein tyrosine phosphatases and enhances insulin signaling in hepatocytes. SBI-0802767 is used in studies of obesity-related type 2 diabetes and insulin resistance.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 68220-27-9
分子式: C₁₂H₉Cl₂N₅
分子量:294.14

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SBI-0802767 構造式

CAS 番号: 68220-27-9

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生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

体外実験

SBI-0802767 (Compound 3) inhibits human LMPTP-A with an IC₅₀ of 0.239 μM and displays >1000-fold selectivity for LMPTP over other PTPs^[1].
SBI-0802767 acts as an uncompetitive inhibitor of LMPTP^[1].
SBI-0802767 shows moderate plasma protein binding and good microsomal stability in in vitro metabolic studies^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC	T_1/2	F	CL_plasma	V_d
Mice^[1]	2 mg/kg	i.v.	/	/	/	/	5.8 mL/min/kg	3.01 L/kg
Mice^[1]	10 mg/kg	p.o.	5018 ng/mL	18544 ng·h/mL	4.71 h	66 %	/	/

体内実験

SBI-0802767 (Compound 3) shows good oral bioavailability (F% = 66) and favorable pharmacokinetic properties in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 68220-27-9
分子量 294.14
分子式 C₁₂H₉Cl₂N₅
SMILES

ClC1=CC=CC(Cl)=C1CN2C=NC(N)=C3N=CN=C32
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Stanford SM, et al. Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J Med Chem. 2021;64(9):5645-5653. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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