SCH 336
Based on 1 Customer Validation
SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.63%
- CAS 番号: 447459-51-0
- 分子式: C23H25NO8S3
- 分子量:539.64
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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hCB2-R |
SCH 336 (Sch.336) (0-10 µM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Ki of 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50 of 2 nM, decreases potency on CB1-containing membranes with EC50 of 200 nM[1].
SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50 of 34 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female B6D2/F1 mice (HU210)[1]
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Dosage:0.02, 0.2, 2.0 mg/kg
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Administration:I.p.
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Result:Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.
化学情報
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CAS 番号 447459-51-0
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性状 Solid
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分子量 539.64
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分子式 C23H25NO8S3
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Color White to off-white
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SMILES
CS(N[C@H](C1=CC=C(C=C1)S(C2=C(C=C(C=C2)OC)S(=O)(C3=CC=C(C=C3)OC)=O)(=O)=O)C)(=O)=O
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別名
SCH-225336
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (185.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
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- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8531 mL | 9.2654 mL | 18.5309 mL | 46.3272 mL |
| 5 mM | 0.3706 mL | 1.8531 mL | 3.7062 mL | 9.2654 mL | |
| 10 mM | 0.1853 mL | 0.9265 mL | 1.8531 mL | 4.6327 mL | |
| 15 mM | 0.1235 mL | 0.6177 mL | 1.2354 mL | 3.0885 mL | |
| 20 mM | 0.0927 mL | 0.4633 mL | 0.9265 mL | 2.3164 mL | |
| 25 mM | 0.0741 mL | 0.3706 mL | 0.7412 mL | 1.8531 mL | |
| 30 mM | 0.0618 mL | 0.3088 mL | 0.6177 mL | 1.5442 mL | |
| 40 mM | 0.0463 mL | 0.2316 mL | 0.4633 mL | 1.1582 mL | |
| 50 mM | 0.0371 mL | 0.1853 mL | 0.3706 mL | 0.9265 mL | |
| 60 mM | 0.0309 mL | 0.1544 mL | 0.3088 mL | 0.7721 mL | |
| 80 mM | 0.0232 mL | 0.1158 mL | 0.2316 mL | 0.5791 mL | |
| 100 mM | 0.0185 mL | 0.0927 mL | 0.1853 mL | 0.4633 mL |
SCH 336 関連分類
HY-121852 関連分類
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