SHLP2
Based on 1 Customer Validation
SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinson’s disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.09%
- CAS 番号: 1191923-93-9
- 分子式: C142H214N36O35S
- 分子量:3017.50
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
SHLP2 (2.5 μM, 24 h) protects against mitochondrial dysfuction in SH-SY5Y cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:2.5 μM
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Incubation Time:24 h
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Result:Reduced the MPP + -induced cell death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1191923-93-9
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性状 Solid
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分子量 3017.50
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分子式 C142H214N36O35S
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Color White to off-white
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別名
Small humanin-like peptide 2
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配列
Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser
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シーケンスの短縮
MGVKFFTLSTRFFPSVQRAVPLWTNS
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (33.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Nashine S, et al. Effects of mitochondrial-derived peptides (MDPs) on mitochondrial and cellular health in AMD[J]. Cells, 2020, 9(5): 1102. [Content Brief]
[2]. Kim, S. J., et al., (2024). A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Molecular psychiatry, 29(2), 505–517. [Content Brief]
[3]. Kim, S. K., et al., (2023). Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons. Nature communications, 14(1), 4321. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3314 mL | 1.6570 mL | 3.3140 mL | 8.2850 mL |
| 5 mM | 0.0663 mL | 0.3314 mL | 0.6628 mL | 1.6570 mL | |
| 10 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8285 mL | |
| 15 mM | 0.0221 mL | 0.1105 mL | 0.2209 mL | 0.5523 mL | |
| 20 mM | 0.0166 mL | 0.0829 mL | 0.1657 mL | 0.4143 mL | |
| 25 mM | 0.0133 mL | 0.0663 mL | 0.1326 mL | 0.3314 mL | |
| 30 mM | 0.0110 mL | 0.0552 mL | 0.1105 mL | 0.2762 mL |
SHLP2 関連分類
HY-P10409 関連分類
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