SL44
Based on 1 Customer Validation
SL44 is an agonist for human caseinolytic protease P (HsClpP), with an EC50 of 1.30 μM. SL44 inhibits the proliferation of LM3 with an IC50 of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD50=400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.57%
- CAS 番号: 3054715-45-3
- 分子式: C22H20ClFN4O
- 分子量:410.87
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCCLM3 | IC50 |
0.4 μM
Compound: SL44
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Antiproliferative activity against human HCCLM3 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
Antiproliferative activity against human HCCLM3 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
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[PMID: 38905539] |
| HCCLM3 | IC50 |
19.1 μM
Compound: SL44
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Antiproliferative activity against human HCCLM3 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
Antiproliferative activity against human HCCLM3 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 2.5 +/- 0.1 microM)
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[PMID: 38905539] |
| HCCLM3 | IC50 |
3.1 μM
Compound: SL44
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Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 38905539] |
| HepG2 | IC50 |
0.9 μM
Compound: SL44
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Antiproliferative activity against human HepG2 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
Antiproliferative activity against human HepG2 cells overexpressing HsClpP assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
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[PMID: 38905539] |
| HepG2 | IC50 |
10.1 μM
Compound: SL44
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 38905539] |
| HepG2 | IC50 |
18.5 μM
Compound: SL44
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Antiproliferative activity against human HepG2 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
Antiproliferative activity against human HepG2 cells harboring HsClpP knockdown assessed as inhibition of cell growth (Rvb = 3.5 +/- 0.1 microM)
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[PMID: 38905539] |
化学情報
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CAS 番号 3054715-45-3
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性状 Solid
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分子量 410.87
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分子式 C22H20ClFN4O
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Color White to off-white
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SMILES
ClC1=C(F)C=CC(CC2=NOC(C3CCN(CC4=CC=CC(C#N)=C4)CC3)=N2)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 70 mg/mL (170.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4339 mL | 12.1693 mL | 24.3386 mL | 60.8465 mL |
| 5 mM | 0.4868 mL | 2.4339 mL | 4.8677 mL | 12.1693 mL | |
| 10 mM | 0.2434 mL | 1.2169 mL | 2.4339 mL | 6.0846 mL | |
| 15 mM | 0.1623 mL | 0.8113 mL | 1.6226 mL | 4.0564 mL | |
| 20 mM | 0.1217 mL | 0.6085 mL | 1.2169 mL | 3.0423 mL | |
| 25 mM | 0.0974 mL | 0.4868 mL | 0.9735 mL | 2.4339 mL | |
| 30 mM | 0.0811 mL | 0.4056 mL | 0.8113 mL | 2.0282 mL | |
| 40 mM | 0.0608 mL | 0.3042 mL | 0.6085 mL | 1.5212 mL | |
| 50 mM | 0.0487 mL | 0.2434 mL | 0.4868 mL | 1.2169 mL | |
| 60 mM | 0.0406 mL | 0.2028 mL | 0.4056 mL | 1.0141 mL | |
| 80 mM | 0.0304 mL | 0.1521 mL | 0.3042 mL | 0.7606 mL | |
| 100 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.6085 mL |
SL44 関連分類
HY-162650 関連分類
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