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製品番号: HY-189060

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SLU-12091

SLU-12091 is a phosphodiesterase (PDE) inhibitor and the more potent enantiomer of rac-11. SLU-12091 inhibits the activities of hPDE5, hPDE11, hPDE2A1, hPDE3A, hPDE3B, hPDE4A1A and hPDE4D2. SLU-12091 inhibits the growth of Cryptosporidium parvum without inhibiting the growth of host cells at the highest concentration tested. SLU-12091 can be used for the research of cryptosporidiosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3065124-09-3
分子式: C₂₃H₂₃BFN₅O₂
分子量:431.27

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SLU-12091 構造式

CAS 番号: 3065124-09-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]

PDE5

PDE11

PDE2A

PDE3A

PDE3B

PDE4A1

PDE4D2

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	EC50	0.011 μM	Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion. Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.	42593902
HCT-8	EC90	0.020 μM	90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion. 90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.	42593902

体外実験

SLU-12091 (ent2-11) (0.011 μM; 48 h) potently inhibits Cryptosporidium parvum replication in HCT-8 cells with an EC₅₀ of 11 nM and shows no cytotoxicity against HCT-8 cells up to 50 μM^[1].
SLU-12091 (0.1-10 μM) inhibits multiple human PDE enzymes, with the strongest activity against hPDE5, hPDE4D2, hPDE3A, hPDE3B, and hPDE2A1 at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3065124-09-3
分子量 431.27
分子式 C₂₃H₂₃BFN₅O₂
SMILES

FC1=CC=C(C=C1)CNC2=NC(C3=CC=C4B(O[C@H](C4=C3)C)O)=NC5=C2C(CC)=NN5C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Guin S, et al. Structure-Activity Relationship Study of Anti-Cryptosporidium Benzoxaboroles Yields Enhanced Potency and Curative Efficacy. Journal of medicinal chemistry. 2026 Aug 13;69(15):19355-19370.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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