SM-11044
SM-11044 is a β-adrenoceptor agonist with Ki values of 18.1 μM (β1), 4.1 μM (β2) and 1.3 μM (β3), showing higher binding selectivity for the β3-adrenoceptor. SM-11044 stimulates cAMP accumulation in cells expressing this receptor. SM-11044 mediates ileal relaxation, tracheal relaxation, pulmonary parenchymal relaxation, increased right atrial heart rate and adipocyte lipolysis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 142784-65-4
- 分子式: C22H28BrFN2O4
- 分子量:483.37
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Adrenergic Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
β1 adrenoceptor 18.1 μM (Ki) |
β2 adrenoceptor 4.1 μM (Ki) |
β3 adrenoceptor 1.3 μM (Ki) |
SM-11044 (Serial dilutions; 1 h) binds to β1-, β2-, and β3-adrenoceptors expressed in CHO cells with highest affinity for β3-adrenoceptors (Ki = 1 μM), followed by β2-adrenoceptors (Ki = 4 μM), and lowest affinity for β1-adrenoceptors (Ki = 18 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 142784-65-4
-
分子量 483.37
-
分子式 C22H28BrFN2O4
-
SMILES
O[C@H](C1=CC(O)=C(C=C1)O)[C@H](NCCCC2=CC=C(C=C2)F)C(N3CCCC3)=O.Br
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SM-11044 関連分類
HY-182640 関連分類
Powered by Bioz