Sodium caseinates
Based on 1 Customer Validation
Sodium caseinates is a kind of sodium salts of major milk proteins, which act as protein-based biopolymers and innate immune system activators. Sodium caseinates induce granulopoiesis, activation and differentiation, promote the production of M-CSF, and increase serum levels of G-CSF and GM-CSF. Sodium caseinates inhibit the proliferation and reduce the viability of leukemia macrophage-like cells, thereby significantly improving the survival rate of mice inoculated with leukemia cells. Sodium caseinates can serve as carriers for probiotics in edible films and exhibit anti-Listeria activity. Sodium caseinates effectively protect vitamin A from degradation, enhance its stability, bioaccessibility and bioavailability, and regulate protein digestibility when complexed with vitamin A. Sodium caseinates can be applied to research related to acute monocytic leukemia and vitamin A deficiency.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 9005-46-3
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Sodium caseinates induce differentiation of mouse bone marrow band granulocytes and increase their M-CSF production in vitro[1].
Sodium caseinate (4% (w/v); 9 days at 4°C) films containing Lactobacillus acidophilus exhibit significant antilisterial activity against Listeria monocytogenes PTCC 1163 after 9 days at 4°C, while films containing Lactobacillus casei only show significant activity after 6 days at 4°C compared to control sodium caseinate films[2].
Sodium caseinates (0.5-2.0 mg/mL; 72 h) inhibits proliferation and induces macrophagic differentiation of J774 leukaemia macrophage-like cells without reducing cell viability[3].
Sodium caseinates (2.0 mg/mL; 24-120 h) inhibits proliferation of J774 leukaemia macrophage-like cells starting at 48 h and significantly reduces cell viability to ~15% after 120 h of incubation[3].
Sodium caseinates (13 μM VA; 20 h) do not exhibit cytotoxicity toward Caco-2 cells, resulting in 80-90% cell viability after 20 h of incubation with 13 μM VA[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774 leukaemia macrophage-like cells
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Concentration:0.5 mg/mL; 1.0 mg/mL; 2.0 mg/mL
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Incubation Time:72 h
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Result:Reduced J774 cell proliferation index to ~50% at 1.0 mg/mL.
Reduced J774 cell proliferation index to ~40% at 2.0 mg/mL.
Did not reduce J774 cell viability at 0.5, 1.0, and 2.0 mg/mL.
Induced macrophagic differentiation of J774 cells at 1.0 and 2.0 mg/mL.
Sodium caseinate (1 mL of 10% (w/v); i.p.; every 48 hours) increases survival of J774-induced leukaemic BALB/c mice to 60% in females and 50% in males at 160 days, while reducing splenomegaly, hepatomegaly, and tumour burden[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (male, 8-12 weeks old)[1]
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Dosage:10% (w/v) in PBS, 1 mL per dose
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Administration:i.p.; four times every 48 hours; 6 days
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Result:Increased total bone marrow leukocyte count to 34.6 × 106 cells per femur, and mononuclear cell count to 4.8 × 106 cells per femur.
Increased percentage of myeloblasts, band cells, and segmented granulocytes in bone marrow, with a corresponding decrease in lymphocyte population.
Increased BrdU incorporation in bone marrow mononuclear cells to 34.86%, and increased percentage of BrdU+/Gr-1+ granulocytic lineage cells to 64.94%.
Increased serum G-CSF levels to 3189 pg/mL, and increased bone marrow plasma G-CSF levels to 1160 pg/mL; serum GM-CSF levels were detectable at 1.25 pg/mL.
Increased granulocyte phagocytic index to 0.6.
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Animal Model:BALB/c (8-12 weeks old; female and male; intraperitoneal inoculation with 1.0×106 J774 leukaemia macrophage-like cells)[3]
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Dosage:1 mL of 10% (w/v)
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Administration:i.p.; every 48 hours
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Result:Significantly reduced splenomegaly, hepatomegaly, and solid tumour burden in leukaemic mice.
Extended survival of treated mice: 60% of female mice survived beyond 160 days, and 50% of male mice survived beyond 160 days (all untreated leukaemic mice died before 100 days).
Eliminated residual autonomous leukaemic cell growth, as mononuclear bone marrow cells isolated from treated surviving mice did not proliferate in vitro without recombinant mouse interleukin-3.
化学情報
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CAS 番号 9005-46-3
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性状 Solid
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Color White to off-white
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SMILES
[Sodium caseinates]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (273 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Domínguez-Melendez V, et al. Sodium caseinate induces mouse granulopoiesis. Inflamm Res. 2012;61(4):367-373. [Content Brief]
[3]. Córdova-Galaviz Y, et al. Sodium caseinate induces increased survival in leukaemic mouse J774 model. In Vivo. 2014;28(5):819-825. [Content Brief]
[4]. Rana S, et al. Effect of sodium caseinate and vitamin A complexation on bioaccessibility and bioavailability of vitamin A in Caco-2 cells. Food Res Int. 2019;121:910-918. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sodium caseinates 関連分類
HY-139410 関連分類
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