Soficitinib
Based on 1 Customer Validation
Soficitinib (Compound 20) is a selective tyrosine kinase 2 (TYK2) and Janus kinase 2 (JAK2) inhibitor, with IC50 values of 0.5 nM and 1.2 nM, respectively. Soficitinib shows promise for research into autoimmune diseases (such as psoriasis, rheumatoid arthritis) and inflammatory diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.54%
- CAS 番号: 2574524-67-5
- 分子式: C18H21ClN8O
- 分子量:400.87
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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JAK2 1.2 nM (IC50) |
Tyk2 0.5 nM (IC50) |
Soficitinib inhibits TYK2 and JAK2 with IC50 values of 0.5 nM and 1.2 nM, respectively[1].
Soficitinib (24 h) inhibits IL-12-induced IFN-γ secretion in NK92 cells, with an IC50 value of 233 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2574524-67-5
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性状 Solid
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分子量 400.87
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分子式 C18H21ClN8O
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Color White to off-white
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SMILES
C[C@]12[C@](CN(C2)C(CC#N)=O)([H])CN(C3=NC(NC4=CN(C)N=C4)=NC=C3Cl)C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (249.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4946 mL | 12.4729 mL | 24.9457 mL | 62.3644 mL |
| 5 mM | 0.4989 mL | 2.4946 mL | 4.9891 mL | 12.4729 mL | |
| 10 mM | 0.2495 mL | 1.2473 mL | 2.4946 mL | 6.2364 mL | |
| 15 mM | 0.1663 mL | 0.8315 mL | 1.6630 mL | 4.1576 mL | |
| 20 mM | 0.1247 mL | 0.6236 mL | 1.2473 mL | 3.1182 mL | |
| 25 mM | 0.0998 mL | 0.4989 mL | 0.9978 mL | 2.4946 mL | |
| 30 mM | 0.0832 mL | 0.4158 mL | 0.8315 mL | 2.0788 mL | |
| 40 mM | 0.0624 mL | 0.3118 mL | 0.6236 mL | 1.5591 mL | |
| 50 mM | 0.0499 mL | 0.2495 mL | 0.4989 mL | 1.2473 mL | |
| 60 mM | 0.0416 mL | 0.2079 mL | 0.4158 mL | 1.0394 mL | |
| 80 mM | 0.0312 mL | 0.1559 mL | 0.3118 mL | 0.7796 mL | |
| 100 mM | 0.0249 mL | 0.1247 mL | 0.2495 mL | 0.6236 mL |
Soficitinib 関連分類
HY-177131 関連分類
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