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製品番号: HY-148012

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SOP1812

Name: SOP1812
Brand: MedChemExpress
SKU: HY-148012
Price: 90.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: QN-302)

カスタマーレビュー

Based on 1 Customer Validation

SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.46%
CAS 番号: 2546091-70-5
分子式: C₄₅H₅₇N₇O₆
分子量:791.98

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SOP1812 構造式

CAS 番号: 2546091-70-5

容量

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	2.6 nM Compound: 11; SOP1812	Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
CAPAN-1	GI₅₀	5.9 nM Compound: 11; SOP1812	Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
MIA PaCa-2	GI₅₀	1.3 nM Compound: 11; SOP1812	Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
PANC-1	GI₅₀	1.4 nM Compound: 11; SOP1812	Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]

体外実験

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells^[1].
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4^[1].
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration:

0-50 nM
Incubation Time:

96 hours
Result:

Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI₅₀ values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay^[1]

Cell Line:

PANC-1 cells
Concentration:

0, 100, 400 and 800 nM
Incubation Time:

6 and 24 hours
Result:

Binded to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively.

Cell Viability Assay^[1]

Cell Line:

MIA PaCa-2 Cells
Concentration:

40 nM
Incubation Time:

6 and 24 hours
Result:

Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.

体内実験

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female athymic nude mice with MIA PaCa-2 xenografts^[1]
Dosage:

1 mg/kg
Administration:

Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result:

Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.

Animal Model:

KPC mice with PDAC symptoms^[1]
Dosage:

1 mg/kg
Administration:

Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result:

Significantly extended survival of KPC mice and showed a better effect than gemcitabine.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2546091-70-5
性状 Solid
分子量 791.98
分子式 C₄₅H₅₇N₇O₆
Color Brown to reddish brown
SMILES

O=C1C2=CC(NCCN3CCCC3)=C4C(N(CCCN5CCOCC5)C(C6=CC(C7=CC=C(CN8CCCC8)C=C7)=C(C2=C64)C(N1CCCN9CCOCC9)=O)=O)=O
別名

QN-302
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (287 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献

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SOP1812

Pyridostatin hydrochloride

CX-5461

360A iodide

Rapamycin

BMVC2

TMPyP4 tosylate

Phen-DC3 Trifluoromethanesulfonate

Pyridostatin TFA

Everolimus

SBE-β-CD

BMVC

APTO-253

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

SOP1812

Pyridostatin hydrochloride

CX-5461

360A iodide

Rapamycin

BMVC2

TMPyP4 tosylate

Phen-DC3 Trifluoromethanesulfonate

Pyridostatin TFA

Everolimus

SBE-β-CD

BMVC

APTO-253

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

SOP1812 関連分類

HY-148012 関連分類

Bioz