SPA107
SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC50 of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC50 of 0.5 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 179939-69-6
- 分子式: C31H48N4O4
- 分子量:540.74
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.5 nM
Compound: 11, SPA107
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Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay
Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay
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[PMID: 12608848] |
| MCF7 | IC50 |
0.5 nM
Compound: 11, SPA107
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Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay
Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay
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[PMID: 12608848] |
化学情報
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CAS 番号 179939-69-6
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分子量 540.74
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分子式 C31H48N4O4
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SMILES
COC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O
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別名
Hemiasterlin methyl ester
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SPA107 関連分類
HY-164923 関連分類
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