Tafamidis-d3
Based on 1 Customer Validation
Tafamidis-d3 (Fx-1006A-d3 (free acid)) is the deuterated-labeled Tafamidis (HY-14852). Tafamidis (Fx-1006A (free acid)) is an orally active and selective transthyretin (TTR) stabilizer. Tafamidis binds to the thyroxine binding site with negative cooperativity, stabilizes the TTR tetramer, slows TTR tetramer dissociation and subunit exchange, and inhibits TTR fibril formation. Tafamidis can be used in research on nervous system-related diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.39%
- 分子式: C14H4D3Cl2NO3
- 分子量:311.13
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
EC50: 2.7-3.2 μM (TTR)[1]
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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非標識Cas 594839-88-0
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性状 Solid
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分子量 311.13
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分子式 C14H4D3Cl2NO3
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Color White to off-white
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SMILES
O=C(C1=C([2H])C([2H])=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1[2H])O
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別名
Fx-1006A-d3 free acid
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 37.5 mg/mL (120.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (285 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2141 mL | 16.0705 mL | 32.1409 mL | 80.3523 mL |
| 5 mM | 0.6428 mL | 3.2141 mL | 6.4282 mL | 16.0705 mL | |
| 10 mM | 0.3214 mL | 1.6070 mL | 3.2141 mL | 8.0352 mL | |
| 15 mM | 0.2143 mL | 1.0714 mL | 2.1427 mL | 5.3568 mL | |
| 20 mM | 0.1607 mL | 0.8035 mL | 1.6070 mL | 4.0176 mL | |
| 25 mM | 0.1286 mL | 0.6428 mL | 1.2856 mL | 3.2141 mL | |
| 30 mM | 0.1071 mL | 0.5357 mL | 1.0714 mL | 2.6784 mL | |
| 40 mM | 0.0804 mL | 0.4018 mL | 0.8035 mL | 2.0088 mL | |
| 50 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6070 mL | |
| 60 mM | 0.0536 mL | 0.2678 mL | 0.5357 mL | 1.3392 mL | |
| 80 mM | 0.0402 mL | 0.2009 mL | 0.4018 mL | 1.0044 mL | |
| 100 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8035 mL |
Tafamidis-d3 関連分類
HY-14852S 関連分類
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