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製品番号: HY-P9981

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Biologically Validated

Tafasitamab

Name: Tafasitamab
Brand: MedChemExpress
SKU: HY-P9981
Price: 290.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(別名: XmAb5574; MOR00208; Tafasitamab-cxix; MOR-208)

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.71%
CAS 番号: 1422527-84-1
分子量:147.42 kDa

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tafasitamab 構造式

CAS 番号: 1422527-84-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Verified Bioactivity
化学情報
Publications (2)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19^[1]^[2].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD19

体外実験

Tafasitamab (XmAb5574) induces cytotoxicity against Mino and Jeko (MCL) cell lines in an E/T ratio-dependent manner. Tafasitamab (XmAb5574) increases ADCP and antiproliferative activity. Tafasitamab (XmAb5574) enhances antiproliferative apoptotic activity due to caspase-induced apoptosis^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

NHL cell lines and primary CLL and MCL cells by γδ T cells
Concentration:
Incubation Time:

2 h
Result:

Induced killing of NHL cell lines and primary CLL and MCL cells by γδ T cells.

Cell Proliferation Assay^[2]

Cell Line:

SU-DHL-6 cells
Concentration:
Incubation Time:

72 h
Result:

Showed potent antiproliferative effects on tumor cell.

Apoptosis Analysis^[2]

Cell Line:

SU-DHL-6 cells
Concentration:

0-4 ng/mL
Incubation Time:

48 h
Result:

Showed potent antiproliferative effects due to caspase-induced apoptosis

体内実験

Tafasitamab (SC, once on Day 1, 2.5 μg/kg) inhibits lymphoma growth in disseminated BL mouse xenograft tumor models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Disseminated Raji model^[1].
Dosage:

2.5 μg/kg
Administration:

Tafasitamab (SC, once on Day 1, 2.5 μg/kg)
Result:

Showed antitumor activity in disseminated Raji model.

Animal Model:

Disseminated Ramos model^[1].
Dosage:

10 mg/kg
Administration:

Tafasitamab (IV, on Days 3, 6, 10, 13, 17, and 20 at a dose of 10 mg/kg)
Result:

Showed antitumor activity in disseminated Ramos model.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

遺伝子ID

930 [NCBI]

アクセッション番号

P15391

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-G2-kappa

アプリケーション

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized CD19 Protein, Human (HEK293, His, HY-P74330) can bind Tafasitamab. The EC₅₀ for this effect is 29.1 ng/mL.
Tafasitamab has a significant ADCP effect on Raji cells in a dose-dependent manner.The EC₅₀ for this effect is 95.42 and 117.87 ng/mL.

化学情報

CAS 番号 1422527-84-1
性状 Liquid
分子量 147.42 kDa
Color Colorless to light yellow
SMILES

[Tafasitamab]
別名

XmAb5574; MOR00208; Tafasitamab-cxix; MOR-208
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

All

Sort by:

Journal Impact Factor

Cytotherapy

2026 May 16.
Clin Chem Lab Med

Tafasitamab interference in immunofixation electrophoresis. [Abstract]

2025 Sep 15. PMID: 40965972

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (262 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Jung Hyun Her, et al. Tafasitamab mediates killing of B-cell non-Hodgkin's lymphoma in combination with γδ T cell or allogeneic NK cell therapy. Cancer Immunol Immunother. 2022 Mar 29. [Content Brief]

[2]. Holly M Horton, et al. Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia. Cancer Res [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Tafasitamab

2 Cited Publications

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生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Biological Activity
化学情報
Publications (2)
純度とドキュメンテーション
参考文献

1/16

IgG1-G2-kappa
1/16

Immobilized CD19 Protein, Human (HEK293, His, HY-P74330) can bind Tafasitamab. The EC₅₀ for this effect is 29.1 ng/mL.
1/16

Tafasitamab has a significant ADCP effect on Raji cells in a dose-dependent manner.The EC₅₀ for this effect is 95.42 and 117.87 ng/mL.
1/16

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MedChemExpress（MCE）の使用を引用している文献 Tafasitamab

生物活性

化学情報

Publications (2)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Tafasitamab

Protein A Agarose

Bradford Protein Assay Kit

Cell-ATP Viability Detection Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Inebilizumab

Rituximab

Obexelimab

Enoblituzumab

Blinatumomab

Human IgG1 kappa, Isotype Control

Enzalutamide

Adagrasib

Obinutuzumab (FUT8-KO)

Datopotamab deruxtecan (solution)

Polatuzumab vedotin

Sacituzumab govitecan

MedChemExpress（MCE）の使用を引用している文献 Tafasitamab

生物活性

化学情報

Publications (2)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Tafasitamab 関連分類

HY-P9981 関連分類

Bioz