TAK-448
Based on 3 publication(s) in Google Scholar
TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.
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- 純度: 99.90%
- CAS 番号: 1234319-68-6
- 分子式: C58H80N16O14
- 分子量:1225.36
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 TAK-448
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生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)
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Dosage:0.01, 0.03, 0.3, 3 mg/kg
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Administration:Given i.h.; dosings on day 0 and 28
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Result:Had greater anti-tumor effects in VCaP xenograft model.
化学情報
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CAS 番号 1234319-68-6
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性状 Solid
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分子量 1225.36
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分子式 C58H80N16O14
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Color White to off-white
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別名
MVT-602
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シーケンスの短縮
Ac-{d-Tyr}-{Hyp}-NTF-{Aza-Gly}-L-{Arg(Me)}-W-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chem
A Computational Integration Strategy Driven by Chemical Similarity Uncovers Comprehensive Metabolic Profiles of Small Bioactive Peptides via UHPLC-HRMS for Doping Control. [Abstract]2025 Nov 18;97(45):25158-25167. PMID: 41202118 -
Cells
Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease. [Abstract]2025 Aug 20;14(16):1289. PMID: 40862768 -
溶剤 & 溶解度
H2O : 100 mg/mL (81.61 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. 1.Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811. [Content Brief]
[2]. Ishikawa K,et al. Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitiveprostate cancer model. Eur J Pharmacol. 2018 Jun 5;828:126-134. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8161 mL | 4.0804 mL | 8.1609 mL | 20.4022 mL |
| 5 mM | 0.1632 mL | 0.8161 mL | 1.6322 mL | 4.0804 mL | |
| 10 mM | 0.0816 mL | 0.4080 mL | 0.8161 mL | 2.0402 mL | |
| 15 mM | 0.0544 mL | 0.2720 mL | 0.5441 mL | 1.3601 mL | |
| 20 mM | 0.0408 mL | 0.2040 mL | 0.4080 mL | 1.0201 mL | |
| 25 mM | 0.0326 mL | 0.1632 mL | 0.3264 mL | 0.8161 mL | |
| 30 mM | 0.0272 mL | 0.1360 mL | 0.2720 mL | 0.6801 mL | |
| 40 mM | 0.0204 mL | 0.1020 mL | 0.2040 mL | 0.5101 mL | |
| 50 mM | 0.0163 mL | 0.0816 mL | 0.1632 mL | 0.4080 mL | |
| 60 mM | 0.0136 mL | 0.0680 mL | 0.1360 mL | 0.3400 mL | |
| 80 mM | 0.0102 mL | 0.0510 mL | 0.1020 mL | 0.2550 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
TAK-448 関連分類
HY-P0076 関連分類
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