TC8026
TC8026 is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI), with an IC50 of 7 μM against human PDI. TC8026 induces endoplasmic reticulum stress-mediated apoptosis. TC8026 is a hit compound with PDI inhibitory activity identified via high-throughput screening, and it can be used for the research of glioblastoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C14H12ClN3O2
- 分子量:289.72
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Compound 30z (120-180 mg/kg; i.p.; single dose) exhibits no acute toxicity in male C57BL/6 mice, with no observable liver or kidney injury[1].
Compound 30z (40 mg/kg; i.p.; once daily) significantly inhibits subcutaneous U251 glioblastoma xenograft growth in female athymic nude mice with good in vivo tolerability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 8 weeks old)[1]
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Dosage:10-40 mg/kg
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Administration:i.p.; once daily; 7 consecutive days
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Result:Exhibited normal body weight gain comparable to vehicle controls.
Maintained serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and blood urea nitrogen (BUN) levels within normal ranges with no significant differences from vehicle controls.
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Animal Model:C57BL/6 (male, 8 weeks old)[1]
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Dosage:120-180 mg/kg
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Administration:i.p.; single dose
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Result:Showed no mortality or adverse clinical signs over the 7-day monitoring period.
Had body weight changes comparable to vehicle controls.
Maintained serum ALT, AST, and BUN levels within normal ranges with no significant differences from vehicle controls.
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Animal Model:athymic nude (nu/nu) (female, 6 weeks old; subcutaneous glioblastoma xenograft model)[1]
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Dosage:40 mg/kg
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Administration:i.p.; once daily
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Result:Significantly suppressed subcutaneous U251 glioblastoma tumor growth compared to vehicle controls, as measured by reduced tumor volume over time and lower terminal tumor weights.
Had body weight changes comparable to vehicle controls, indicating good tolerability.
化学情報
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分子量 289.72
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分子式 C14H12ClN3O2
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SMILES
O=C(N1CC#CC(NCC)=O)C2=C(N=C1Cl)C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TC8026 関連分類
HY-181573 関連分類
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