Tesirine intermediate-2
Based on 1 Customer Validation
Tesirine intermediate-2 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.43%
- CAS 番号: 1430738-34-3
- 分子式: C40H55N5O10Si
- 分子量:793.98
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-101160
SG2057PBD Dimer -
HY-34758
N-Nitroso-N-methylureaCarcinogen Agent -
HY-111375
AzoxymethaneGenotoxic Carcinogen -
HY-128612
MethylnitronitrosoguanidineAlkylating Agent -
HY-13585
CarmustineDNA/RNA Alkylator -
HY-17420A
Cyclophosphamide hydrateAlkylating Agent -
HY-13593
ChlorambucilDNA Alkylator -
HY-101161
SG3199PBD Dimer -
HY-129241
AGX51ID Protein Antagonist -
HY-13424
RITAp53-HDM-2 Interaction Inhibitor -
HY-13747
SemustineAntitumor Alkylating Agent -
HY-13543
TretazicarDNA Cross-linking Agent
生物活性
製品説明
化学情報
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CAS 番号 1430738-34-3
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性状 Solid
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分子量 793.98
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分子式 C40H55N5O10Si
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Color White to off-white
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SMILES
CC(C)(C)[Si](C)(C)O[C@@H]1N(C2=CC(O)=C(OC)C=C2C(N3[C@@]1([H])CC(C)=C3)=O)C(OCC4=CC=C(C=C4)NC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 200 mg/mL (251.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2595 mL | 6.2974 mL | 12.5948 mL | 31.4869 mL |
| 5 mM | 0.2519 mL | 1.2595 mL | 2.5190 mL | 6.2974 mL | |
| 10 mM | 0.1259 mL | 0.6297 mL | 1.2595 mL | 3.1487 mL | |
| 15 mM | 0.0840 mL | 0.4198 mL | 0.8397 mL | 2.0991 mL | |
| 20 mM | 0.0630 mL | 0.3149 mL | 0.6297 mL | 1.5743 mL | |
| 25 mM | 0.0504 mL | 0.2519 mL | 0.5038 mL | 1.2595 mL | |
| 30 mM | 0.0420 mL | 0.2099 mL | 0.4198 mL | 1.0496 mL | |
| 40 mM | 0.0315 mL | 0.1574 mL | 0.3149 mL | 0.7872 mL | |
| 50 mM | 0.0252 mL | 0.1259 mL | 0.2519 mL | 0.6297 mL | |
| 60 mM | 0.0210 mL | 0.1050 mL | 0.2099 mL | 0.5248 mL | |
| 80 mM | 0.0157 mL | 0.0787 mL | 0.1574 mL | 0.3936 mL | |
| 100 mM | 0.0126 mL | 0.0630 mL | 0.1259 mL | 0.3149 mL |
Tesirine intermediate-2 関連分類
HY-24144 関連分類
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