Thiacloprid
Based on 1 publication(s) in Google Scholar
Thiacloprid is an orally active neurotoxic insecticide and also a nAChR agonist. Thiacloprid reduces the viability of healthy cells, depletes reduced glutathione, and increases MDA levels, thereby inducing cytotoxicity and oxidative stress damage. In practical applications, Thiacloprid has lower acute toxicity to honeybees than other compounds of the same class such as Imidacloprid (HY-B0838), but it still significantly impairs the learning and memory function, immune capacity and survival status of honeybees. Thiacloprid induces intestinal microbial dysbiosis and reduces survival rate in middle-aged honeybees, increases the risk of premature collapse in bumblebee colonies, and significantly decreases the final colony weight and reproductive output. Thiacloprid is used in broad-spectrum agricultural pest control, often alone or in combination with Deltamethrin (HY-B1971), and meets the pest management needs of various crops including potatoes, cabbages, various fruits and vegetables, and nuts.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.66%
- CAS 番号: 111988-49-9
- 分子式: C10H9ClN4S
- 分子量:252.72
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Thiacloprid
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SH-SY5Y | IC50 |
100 μM
Compound: THIA
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Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells
Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells
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[PMID: 11312774] |
| TE-671 | IC50 |
120 μM
Compound: THIA
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Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta1 nicotinic acetylcholine receptor subunits
Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta1 nicotinic acetylcholine receptor subunits
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[PMID: 11312774] |
Combination treatment with Thiacloprid (7.5-3000 μM; 24-72 h) and Deltamethrin (HY-B1971) reduces the viability of human lung fibroblast cell line WTHBF-6 in a time- and concentration-dependent manner. Specifically, significant viability reduction is observed at concentrations of 1500 μM, 2250 μM and 3000 μM after 48 h and 72 h of treatment, as well as at 750 μM after 72 h of treatment[1].
Thiacloprid (75-375 μM; 24-72 h) significantly reduces the level of GSH, increases the level of malondialdehyde (MDA), and induces cellular lipid peroxidation damage in human lung fibroblast cell line WTHBF-6[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WTHBF-6 (human telomerase reverse transcriptase (hTERT)-expressing human lung fibroblasts)
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Concentration:7.5 μM, 18.75 μM, 37.5 μM, 75 μM, 187.5 μM, 375 μM, 750 μM, 1500 μM, 2250 μM, 3000 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Co-administered with Deltamethrin at a fixed concentration ratio of 7.5:1.
Reduced the viability of WTHBF-6 cells in a time- and concentration-dependent manner.
Significantly decreased cell viability at the concentrations of 1500 μM, 2250 μM and 3000 μM of Thiacloprid after 48 h and 72 h treatment, and at 750 μM of Thiacloprid (HY-B1953) after 72 h treatment, compared with the 0.1% DMSO vehicle control group.
Thiacloprid (recommended manufacturer spray rate; free foraging on treated crop flowers) under field-realistic exposure to treated raspberry crops leads to accumulation of thiacloprid residues in bumblebee colony food stores, with maximum concentrations of 771 ppb in pollen and 561 ppb in nectar[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bombus terrestris audax (commercially reared colonies)[3]
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Dosage:recommended manufacturer spray rate
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Administration:free foraging on treated crop flowers
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Result:Detected thiacloprid residues in pollen and nectar stores up to 771 ppb in pollen and 561 ppb in nectar 2-4 weeks postspraying.
Detected no thiacloprid in nectar and only minimal levels in pollen at 4 weeks (pre-spraying).
化学情報
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CAS 番号 111988-49-9
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性状 Solid
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分子量 252.72
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分子式 C10H9ClN4S
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Color White to off-white
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SMILES
N#C/N=C1N(CCS/1)CC(C=C2)=CN=C2Cl
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別名
Thiacloprid
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996
溶剤 & 溶解度
DMSO : 50 mg/mL (197.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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参考文献
[2]. Liu YJ, et al. Thiacloprid exposure perturbs the gut microbiota and reduces the survival status in honeybees. J Hazard Mater. 2020;389:121818. [Content Brief]
[3]. Ellis C, et al. The Neonicotinoid Insecticide Thiacloprid Impacts upon Bumblebee Colony Development under Field Conditions. Environ Sci Technol. 2017;51(3):1727-1732. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9569 mL | 19.7847 mL | 39.5695 mL | 98.9237 mL |
| 5 mM | 0.7914 mL | 3.9569 mL | 7.9139 mL | 19.7847 mL | |
| 10 mM | 0.3957 mL | 1.9785 mL | 3.9569 mL | 9.8924 mL | |
| 15 mM | 0.2638 mL | 1.3190 mL | 2.6380 mL | 6.5949 mL | |
| 20 mM | 0.1978 mL | 0.9892 mL | 1.9785 mL | 4.9462 mL | |
| 25 mM | 0.1583 mL | 0.7914 mL | 1.5828 mL | 3.9569 mL | |
| 30 mM | 0.1319 mL | 0.6595 mL | 1.3190 mL | 3.2975 mL | |
| 40 mM | 0.0989 mL | 0.4946 mL | 0.9892 mL | 2.4731 mL | |
| 50 mM | 0.0791 mL | 0.3957 mL | 0.7914 mL | 1.9785 mL | |
| 60 mM | 0.0659 mL | 0.3297 mL | 0.6595 mL | 1.6487 mL | |
| 80 mM | 0.0495 mL | 0.2473 mL | 0.4946 mL | 1.2365 mL | |
| 100 mM | 0.0396 mL | 0.1978 mL | 0.3957 mL | 0.9892 mL |
Thiacloprid 関連分類
HY-B1953 関連分類
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