Thioglucose
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Thioglucose is a thiosugar with antioxidant properties. Thioglucose acts as an H2S/polysulfide donor to elevate intracellular sulfane sulfur levels and promote hydropersulfide formation. Thioglucose reduces the endocytosis of gold nanoparticles by phagocytes, enhances cytotoxicity and improves biocompatibility by increasing their adsorption on the surface of cancer cells. Thioglucose can be engineered into a stimulus-responsive prodrug or functional reagent for the development of targeted nanocarriers, and is used in studies related to human breast adenocarcinoma and cervical cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.97%
- CAS 番号: 20408-97-3
- 分子式: C6H12O5S
- 分子量:196.22
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保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Thioglucose (100 μM; 1 h) in combination with 10 μg/mL GOx in 50 mM PBS buffer (pH 7.4) produces H2S, as detected by the fluorescent probe WSP5 (HY-129420) after 1 hour at room temperature[2].
Thioglucose-functionalised 50 nm gold nanoparticles (20 ppm) show the highest uptake across HMEC-1, HeLa, and MCF-7 cells, with uptake levels significantly lower than in RAW 264.7 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 20408-97-3
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性状 Solid
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分子量 196.22
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分子式 C6H12O5S
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Color Off-white to yellow
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SMILES
OC[C@@H](S)[C@@H](O)[C@H](O)[C@@H](O)C=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (509.63 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lindahl S, et al. Thioglucose-derived tetrasulfide, a unique polysulfide model compound. Redox Biol. 2024;70:103045. [Content Brief]
[2]. Ni X, et al. A Sweet H2S/H2O2 Dual Release System and Specific Protein S-Persulfidation Mediated by Thioglucose/Glucose Oxidase. J Am Chem Soc. 2021;143(33):13325-13332. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0963 mL | 25.4816 mL | 50.9632 mL | 127.4080 mL |
| 5 mM | 1.0193 mL | 5.0963 mL | 10.1926 mL | 25.4816 mL | |
| 10 mM | 0.5096 mL | 2.5482 mL | 5.0963 mL | 12.7408 mL | |
| 15 mM | 0.3398 mL | 1.6988 mL | 3.3975 mL | 8.4939 mL | |
| 20 mM | 0.2548 mL | 1.2741 mL | 2.5482 mL | 6.3704 mL | |
| 25 mM | 0.2039 mL | 1.0193 mL | 2.0385 mL | 5.0963 mL | |
| 30 mM | 0.1699 mL | 0.8494 mL | 1.6988 mL | 4.2469 mL | |
| 40 mM | 0.1274 mL | 0.6370 mL | 1.2741 mL | 3.1852 mL | |
| 50 mM | 0.1019 mL | 0.5096 mL | 1.0193 mL | 2.5482 mL | |
| 60 mM | 0.0849 mL | 0.4247 mL | 0.8494 mL | 2.1235 mL | |
| 80 mM | 0.0637 mL | 0.3185 mL | 0.6370 mL | 1.5926 mL | |
| 100 mM | 0.0510 mL | 0.2548 mL | 0.5096 mL | 1.2741 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thioglucose 関連分類
HY-W014989 関連分類
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