TL033
Based on 1 Customer Validation
TL033 is a drug-Linker conjugates for ADC. TL033 contains a linker and bioactive small molecule toxins. TL033 can conjugate with Sacituzumab antibody (anti Trop-2) for synthesizing BT001021. BT001021 has anti-cancer activities against various cancers, such as breast cancer, non-small cell lung cancer (NSCLC), gastric cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.11%
- CAS 番号: 2356230-22-1
- 分子式: C76H103N13O23S2
- 分子量:1630.83
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示
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生物活性
BT001021 (3 days) shows killing effects (EC50: 13.15 nM) on HCC1806 cells (breast cancer cell line)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCC1806 (Trop-2 positive cell line)
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Concentration:0-50 nM approximately
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Incubation Time:3 days
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Result:Showed cytoxicity with an EC50 value of 13.15 nM.
BT001021 (intravenous injection, 10 mg/kg for a single dose) shows significant tumor tissue targetability and good pharmacokinetic properties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft of a human gastric cancer cell line NCI-N87[1]
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Dosage:3 mg/kg
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Administration:Intravenous injection, twice a week for a total of 6 times.
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Result:Significantly inhibited the tumor growth (114.61%) without significant toxicity.
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Animal Model:
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Dosage:10 mg/kg
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Administration:Intravenous injection, twice a week for a total of 6 times.
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Result:Effectively inhibited the tumor growth (54.93% for breast cancer, 108.7% for NSCLC).
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Animal Model:Xenograft of a human gastric cancer cell line NCI-N87 (pharmacokinetic assay)[1]
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Dosage:10 mg/kg
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Administration:Intravenous injection for a single dose
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Result:Pharmacokinetic parameters of BT001021 in tumors and serum.
Tumor Serum Cmax (ng/mL) 7.82 11.7/sub> Tmax (h) 8.0 1.0 T1/2 (h) 93.14 44.35
化学情報
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CAS 番号 2356230-22-1
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性状 Solid
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分子量 1630.83
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分子式 C76H103N13O23S2
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Color Light yellow to yellow
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SMILES
O=C1N2C(C3=NC4=CC=CC=C4C(CCN(C(C)C)S(C)(=O)=O)=C3C2)=CC5=C1COC([C@@]5(CC)OC(OCC6=CC=C(C=C6)NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7C=C(N=N7)CNC(CCCC#CC8=CN=C(S(C)(=O)=O)N=C8)=O)=O)=O)=O)=O)=O
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別名
Tirumotecan
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TL033 関連分類
HY-147340 関連分類
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