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United States

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製品番号: HY-131374

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TN14003

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 368874-31-1
分子式: C₉₀H₁₄₁N₃₃O₁₈S₂
分子量:2037.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

TN14003 構造式

CAS 番号: 368874-31-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity^[1].

CXCR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	CC₅₀	410 μM Compound: TN-14003	Cytotoxicity against MDA-MB-231 cells Cytotoxicity against MDA-MB-231 cells	[PMID: 17958344]
MDA-MB-231	IC₅₀	0.6 nM Compound: TN-14003	Inhibition of CXCR4 in MDA-MB-231 cells Inhibition of CXCR4 in MDA-MB-231 cells	[PMID: 17958344]

体内実験

TN14003 (7.5 mg/kg, intraperitoneal injection, 5 days per week) inhibits HER2 tumor growth by reducingangiogenesis and myofibroblast content^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

化学情報

CAS 番号 368874-31-1
分子量 2037.42
分子式 C₉₀H₁₄₁N₃₃O₁₈S₂
配列

Arg-Arg-{Ala-(2-Naph)}-Cys-Tyr-{Cit}-Lys-Lys-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys13)
シーケンスの短縮

RR-{Ala-(2-Naph)}CY-{Cit}-KKPYR-{Cit}-CR-NH2 (Disulfide bridge: Cys4-Cys13)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (258 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lefort S, et al. CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients. Oncogene. 2017 Mar 2;36(9):1211-1222. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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