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製品番号: HY-125426

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ToP-DNJ

ToP-DNJ is a selective endoplasmic reticulum α-glucosidase II (GluII) inhibitor with an IC₅₀ value of 9.0 μM. ToP-DNJ selectively inhibits the two catalytic reactions of GluII, and exhibits stronger activity in the first step of converting di-glycosylated glycans to mono-glycosylated glycans. ToP-DNJ exhibits anti-DENV activity. ToP-DNJ can be used in studies related to dengue virus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1508303-85-2
分子式: C₄₀H₇₁NO₆
分子量:661.99

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ToP-DNJ 構造式

CAS 番号: 1508303-85-2

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

GluII

9.0
μM (IC₅₀)

体外実験

ToP-DNJ is a selective inhibitor of isolated endoplasmic reticulum α-glucosidase II, with an IC₅₀ of 9.0 μM, and does not inhibit other tested α- or β-glucosidases at concentrations up to 50 μM^[1].
ToP-DNJ inhibits both catalytic reactions of isolated endoplasmic reticulum α-glucosidase II, with higher inhibitory potency against the first reaction (IC₅₀ = 14 μM) than against the second one (IC₅₀ = 56 μM)^[1].
ToP-DNJ exhibits anti-dengue virus activity in primary human monocyte-derived macrophages with an IC₅₀ of 12.7 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2 (Elimination)
Mice^[1]	2 mg/kg	i.v.	/	/	8.79 h
Mice^[1]	10 mg/kg	p.o.	46 nM	8 h	/

体内実験

ToP-DNJ (2-10 mg/kg; i.v., p.o.; single dose) preferentially accumulates in the liver of BALB/c mice after both intravenous and oral single-dose administration, with an extended plasma terminal half-life of 8.79 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1508303-85-2
分子量 661.99
分子式 C₄₀H₇₁NO₆
SMILES

O[C@@H]1[C@@H](CO)N(CCCCCOC2=C(C)C(C)=C3C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O3)=C2C)C[C@H](O)[C@H]1O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kiappes JL, et al. ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity. ACS Chem Biol. 2018;13(1):60-65. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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