TRIM
Based on 1 Customer Validation
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.80%
- CAS 番号: 25371-96-4
- 分子式: C10H7F3N2
- 分子量:212.17
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
|
iNOS |
nNOS |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 25371-96-4
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性状 Solid
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分子量 212.17
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分子式 C10H7F3N2
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Color White to off-white
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SMILES
FC(C1=CC=CC=C1N2C=CN=C2)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 250 mg/mL (1178.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350. [Content Brief]
[2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7132 mL | 23.5660 mL | 47.1320 mL | 117.8300 mL |
| 5 mM | 0.9426 mL | 4.7132 mL | 9.4264 mL | 23.5660 mL | |
| 10 mM | 0.4713 mL | 2.3566 mL | 4.7132 mL | 11.7830 mL | |
| 15 mM | 0.3142 mL | 1.5711 mL | 3.1421 mL | 7.8553 mL | |
| 20 mM | 0.2357 mL | 1.1783 mL | 2.3566 mL | 5.8915 mL | |
| 25 mM | 0.1885 mL | 0.9426 mL | 1.8853 mL | 4.7132 mL | |
| 30 mM | 0.1571 mL | 0.7855 mL | 1.5711 mL | 3.9277 mL | |
| 40 mM | 0.1178 mL | 0.5892 mL | 1.1783 mL | 2.9458 mL | |
| 50 mM | 0.0943 mL | 0.4713 mL | 0.9426 mL | 2.3566 mL | |
| 60 mM | 0.0786 mL | 0.3928 mL | 0.7855 mL | 1.9638 mL | |
| 80 mM | 0.0589 mL | 0.2946 mL | 0.5892 mL | 1.4729 mL | |
| 100 mM | 0.0471 mL | 0.2357 mL | 0.4713 mL | 1.1783 mL |
TRIM 関連分類
HY-101316 関連分類
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