Trimyristin
Based on 1 Customer Validation
Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC50 values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.72%
- CAS 番号: 555-45-3
- 分子式: C45H86O6
- 分子量:723.16
-
保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
AChE 0.11 mM (IC50) |
ACP 0.16 mM (IC50) |
ALP 0.18 mM (IC50) |
Trimyristin (0.04-0.15 mM; 15 min preincubation) potently inhibits AChE (IC50 = 0.11 mM), ACP (IC50 = 0.16 mM), and ALP (IC50 = 0.18 mM) in nervous tissue homogenates of Lymnaea acuminata snails via competitive noncompetitive inhibition of AChE and ALP, and uncompetitive inhibition of ACP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Trimyristin (15-30 mg/kg; p.o.; daily; 6 weeks) restores sodium arsenite-induced downregulated cerebral cortex acetylcholinesterase concentrations to baseline control levels in adult male Wistar rats[2].
Trimyristin (15-30 mg/kg; p.o.; daily; 9 weeks) shows that chronic treatment with 30 mg/kg significantly reduces cerebral cortex acetylcholinesterase concentrations in adult male Wistar rats, while 15 mg/kg maintains control-level concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Lymnaea acuminata Lamarck (adults, length 2.25 cm)[1]
-
Dosage:6.21 mg/L (40% of 24 h LC50); 12.43 mg/L (80% of 24 h LC50); 2.80 mg/L (40% of 96 h LC50); 5.60 mg/L (80% of 96 h LC50)
-
Administration:aquatic exposure; 24 or 96 hours
-
Result:Reduced acetylcholinesterase (AChE) activity to 90%, 82%, 73%, and 63% of control levels after exposure to 40% 24 h LC50, 80% 24 h LC50, 40% 96 h LC50, and 80% 96 h LC50 of trimyristin, respectively.
Reduced acid phosphatase (ACP) activity to 87%, 80%, 73%, and 64% of control levels after exposure to 40% 24 h LC50, 80% 24 h LC50, 40% 96 h LC50, and 80% 96 h LC50 of trimyristin, respectively.
Reduced alkaline phosphatase (ALP) activity to 92%, 84%, 71%, and 61% of control levels after exposure to 40% 24 h LC50, 80% 24 h LC50, 40% 96 h LC50, and 80% 96 h LC50 of trimyristin, respectively.
Caused statistically significant (P < .05) concentration- and time-dependent inhibition of AChE, ACP, and ALP, with maximum inhibition of 37% for AChE, 36% for ACP, and 39% for ALP observed at the 80% 96 h LC50 dose.
-
Animal Model:Wistar (adult male, 150-250 g, average 200 g, sodium arsenite-induced neurotoxicity)[2]
-
Dosage:15 mg/kg; 30 mg/kg
-
Administration:p.o.; daily; 6 weeks
-
Result:Significantly upregulated and restored cerebral cortex AChE concentrations to baseline control levels.
Restored normal cytoarchitecture of cerebral cortices, with no significant inflammation or degenerative changes.
-
Animal Model:Wistar (adult male, 150-250 g, average 200 g)[2]
-
Dosage:15 mg/kg; 30 mg/kg
-
Administration:p.o.; daily; 9 weeks
-
Result:Maintained AChE concentrations at levels comparable to control groups (15 mg/kg).
Caused a statistically significant reduction in cerebral cortex AChE concentrations relative to control groups (30 mg/kg).
化学情報
-
CAS 番号 555-45-3
-
性状 Solid
-
分子量 723.16
-
分子式 C45H86O6
-
Color White to off-white
-
SMILES
CCCCCCCCCCCCCC(OC(COC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)=O
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
Acetone : 5 mg/mL (6.91 mM; Need ultrasonic)
DMF : 2.5 mg/mL (3.46 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / Acetone | 1 mM | 1.3828 mL | 6.9141 mL | 13.8282 mL | 34.5705 mL |
| Acetone | 5 mM | 0.2766 mL | 1.3828 mL | 2.7656 mL | 6.9141 mL |
Trimyristin 関連分類
HY-N2511 関連分類
Powered by Bioz