Tyrene
Based on 1 Customer Validation
Tyrene (2,4,6-Trichloroanisole) is an off-flavor compound, cyclic nucleotide-gated (CNG) channel inhibitor, and olfactory transduction attenuator. Tyrene is formed by microbial O-methylation of 2,4,6-trichlorophenol. Tyrene inhibits channel activity in olfactory receptor cells by partitioning into the plasma membrane lipid bilayer, and also suppresses odorant- and cAMP-induced currents in individual olfactory receptor cells. Tyrene causes cork taint in wine. Tyrene also produces off-flavors in potato chips, dried fruits, coffee, and drinking water.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 87-40-1
- 分子式: C7H5Cl3O
- 分子量:211.47
-
保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Tyrene potently inhibits cyclic nucleotide-gated channel-mediated currents in isolated salamander olfactory receptor cells, with an EC50 of 0.19 μM[1].
Tyrene inhibits odorant-induced currents in dissociated salamander olfactory receptor cells[1].
Tyrene inhibits cyclic nucleotide-gated channel-mediated currents in isolated salamander olfactory receptor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 87-40-1
-
性状 Solid
-
分子量 211.47
-
分子式 C7H5Cl3O
-
Color White to off-white
-
SMILES
ClC1=CC(Cl)=C(OC)C(Cl)=C1
-
別名
2,4,6-Trichloroanisole
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
-
データシート (270 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Takeuchi H, et al. 2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16235-40. [Content Brief]
[2]. Taylor MK, et al. Supercritical fluid extraction of 2,4,6-trichloroanisole from cork stoppers. J Agric Food Chem. 2000 Jun;48(6):2208-11. [Content Brief]
[3]. Alvarez-Rodríguez ML, et al. Cork taint of wines: role of the filamentous fungi isolated from cork in the formation of 2,4,6-trichloroanisole by o methylation of 2,4,6-trichlorophenol. Appl Environ Microbiol. 2002 Dec;68(12):5860-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tyrene 関連分類
HY-W097929 関連分類
Powered by Bioz
- Tyrene
- 87-40-1
- 2,4,6-Trichloroanisole
- Olfactory Receptor
- Drug Metabolite
- Biochemical Assay Reagents
- HCN Channel
- olfactory receptor cells
- 2,4,6-trichlorophenol
- SAM-dependent methyltransferase
- cyclic nucleotide-gated channel
- Trichoderma longibrachiatum
- Trichoderma viride
- plasma membrane lipid bilayers
- cAMP
- Fusarium oxysporum
- S-adenosyl-L-homocysteine
- Inhibitor
- inhibitor
- inhibit