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製品番号: HY-P2074

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U 77436

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 128657-36-3
分子式: C₅₀H₇₆N₁₀O₁₁
分子量:993.20

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 77436 構造式

CAS 番号: 128657-36-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension^[1].

体内実験

U 77436 (25 μg/rat; intratracheal administration) achieves an absorption rate of 52.1% in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 400-550 g)^[1]
Dosage:

25 μg/rat (intrapulmonary); 75 μg/rat (intravenous)
Administration:

intrapulmonary; single dose; intravenous; single dose
Result:

Achieved total recovery of 104.9% in bile and urine after intravenous administration, with 93.3% recovered in bile and 11.6% recovered in urine.
Achieved total recovery of 53.7% in bile and urine after intrapulmonary administration, with 48.0% recovered in bile and 5.7% recovered in urine.
Reached 52.1% intrapulmonary absorption relative to intravenous recovery.
Showed 63% of ⁵¹Cr-labeled dose reached the lungs, with an estimated 81% of the lung-delivered dose absorbed by 10 hours.

化学情報

CAS 番号 128657-36-3
分子量 993.20
分子式 C₅₀H₇₆N₁₀O₁₁
SMILES

[O-][N+]1=CC=CC=C1CNC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)C[C@H](O)[C@H](CC(C)C)NC([C@H](CC2=CN=CN2)N(C)C([C@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C(NC(CO)(CO)CO)=O)=O)=O)=O)=O)=O
配列

{Pro(NHCO-NH-C(CH2OH)3)}-Phe-{His(NCH3)}-Leu{(CHOH-CH2)}-Val-{Ile(NHCH2-C5H4NO)}
シーケンスの短縮

{Pro(NHCO‑NH‑C(CH2OH)3)}‑F‑{His(NCH3)}-Leu{(CHOH‑CH2)}-V-{Ile(NHCH2-C5H4NO)}
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Sheehy AM, et al. Intrapulmonary delivery of renin inhibitory peptides results in sustained release because of saturable transport. Pharm Res. 1993 Oct;10(10):1548-51. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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