U-99194
U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 82668-33-5
- 分子式: C17H27NO2
- 分子量:277.40
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Dopamine Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
D3 Receptor |
U-99194 (1 μM, 15 min) prevents the cocaine-induced inhibition of monosynaptic inhibitory postsynaptic currents (IPSCs) evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
U-99194 (1 μM) blocks the inhibitory effect of PD 128907 ( HY-100539) on the amplitude of monosynaptic IPSCs evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
U-99194 (30 μg/site, intracerebellar microinjection, once) markedly inhibits Nicotine-induced tremor in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Nicotine (1 mg/kg, i.p.) was injected to induce kinetic tremor in male ddY mice (7-11 weeks of age)[1]
-
Dosage:30 mg/kg
-
Administration:i.p., once
-
Result:Suppressed Nicotine (HY-127019)-induced tremor.
-
Animal Model:Nicotine (1 mg/kg, i.p.) was injected to induce kinetic tremor in Male SD rats (7-11 weeks of age)[1]
-
Dosage:30 μg/site
-
Administration:intracerebellar microinjection, once
-
Result:Suppressed Nicotine (HY-127019)-induced tremor.
化学情報
-
CAS 番号 82668-33-5
-
分子量 277.40
-
分子式 C17H27NO2
-
SMILES
CCCN(CCC)C1CC2=C(C=C(OC)C(OC)=C2)C1
-
別名
U-99194A free base; PNU-99194A; JPC-211
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kato M, et al. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Front Pharmacol. 2022 Jun 16;13:938175. [Content Brief]
[2]. Hammad H, et al. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. J Pharmacol Exp Ther. 2006 Jan;316(1):113-20. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
U-99194 関連分類
HY-12701 関連分類
Powered by Bioz