Ulinastatin
Based on 5 publication(s) in Google Scholar
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 80449-31-6
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
MedChemExpress(MCE)の使用を引用している文献 Ulinastatin
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Histological Imaging/Staining
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IF
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RT-PCR
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WB
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IHC
生物活性
Ulinastatin (500-5000 U; 24 hours) markedly attenuates TLR4 expression and NF-κB activation in LPS-stimulated BEAS-2B cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human lung epithelial BEAS-2B cells
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Concentration:500 U, 2500 U, 5000 U
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Incubation Time:24 hours
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Result:Markedly attenuated TLR4 expression and NF-κB activation in LPS-stimulated BEAS-2B cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (8-10 weeks old, 18-22 g)[1]
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Dosage:10000 U/kg
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Administration:i.v.; twice (1 h before and 6 h after LPS treatment)
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Result:Significantly protected animals from LPS-induced ALI.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 80449-31-6
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性状 Solid
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Color White to off-white
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SMILES
[Ulinastatin]
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別名
Uristatin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Qingjie Huagong decoction inhibits pancreatic acinar cell pyroptosis by regulating circHipk3/miR-193a-5p/NLRP3 pathway. [Abstract]2024 Apr:126:155265. PMID: 38422649 -
Acta Pharmacol Sin
A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3. [Abstract]2026 Jan 16. PMID: 41545756 -
Eur J Pharmacol
Octreotide attenuates experimental severe acute pancreatitis through inhibiting pyroptosis and modulating intestinal homeostasis. [Abstract]2025 May 5:994:177314. PMID: 39922420 -
J Ovarian Res
2025 Sep 29;18(1):207. PMID: 41024007
Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]
H&E staining results of rat ovaries treated with cisplatin on days 14 and 35 treated with Ulinastatin (15, 30 mg/kg, i.p.).
Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]
TUNEL staining of ovarian tissues of rats treated with Ulinastatin (15, 30 mg/kg, i.p.).
Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]
qPCR results of Keap1, Nrf2, TGFβ-1, FN, Cleaved-caspase3, BAX, and Bcl2 in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on day 14 using Cisplatin.
Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]
WB results of Keap1, Nrf2, TGFβ-1, FN, Cleaved-caspase3, BAX, and Bcl2 in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on days 14 and 35 using Cisplatin.
Ulinastatin purchased from MedChemExpress. Usage Cited in: J Ovarian Res. 2025 Sep 29;18(1):207. [Abstract]
Immunohistochemical results of Keap1, Nrf2, TGFβ-1, and FN in cells of each group after treatment with Ulinastatin (15, 30 mg/kg, i.p.) on day 14 of Cisplatin use.
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溶剤 & 溶解度
H2O : 10 mg/mL (Need ultrasonic)
DMSO : 1 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Shangping Fang, et al. Research progress of ulinastatin in the treatment of liver diseases. Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726. [Content Brief]
[2]. Cao C, et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock. 2018 Nov;50(5):595-605. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)