UPGL00004
Based on 1 publication(s) in Google Scholar
UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 1890169-95-5
- 分子式: C25H26N8O2S2
- 分子量:534.66
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Glutamine Metabolism Compound Library
HY-L064
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Cancer Metabolism Compound Library
HY-L083
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Mitochondria-Targeted Compound Library
HY-L089
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Targeted Diversity Library
HY-L099
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Cuproptosis Compound Library
HY-L133
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Amino Acid Metabolism Compound Library
HY-L189
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High-Throughput Bioactive Compound Library
HY-L205
MedChemExpress（MCE）の使用を引用している文献 UPGL00004
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
70 nM
Compound: 7c
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Cytotoxicity against human MDA-MB-231 cells measured on 6th day by hemocytometry
Cytotoxicity against human MDA-MB-231 cells measured on 6th day by hemocytometry
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[PMID: 26988803] |
UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1890169-95-5
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性状 Solid
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分子量 534.66
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分子式 C25H26N8O2S2
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Color Off-white to gray
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SMILES
O=C(NC1=NN=C(N2CCC(NC3=NN=C(NC(CC4=CC=CC=C4)=O)S3)CC2)S1)CC5=CC=CC=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 125 mg/mL (233.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8703 mL | 9.3517 mL | 18.7035 mL | 46.7587 mL |
| 5 mM | 0.3741 mL | 1.8703 mL | 3.7407 mL | 9.3517 mL | |
| 10 mM | 0.1870 mL | 0.9352 mL | 1.8703 mL | 4.6759 mL | |
| 15 mM | 0.1247 mL | 0.6234 mL | 1.2469 mL | 3.1172 mL | |
| 20 mM | 0.0935 mL | 0.4676 mL | 0.9352 mL | 2.3379 mL | |
| 25 mM | 0.0748 mL | 0.3741 mL | 0.7481 mL | 1.8703 mL | |
| 30 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5586 mL | |
| 40 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1690 mL | |
| 50 mM | 0.0374 mL | 0.1870 mL | 0.3741 mL | 0.9352 mL | |
| 60 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL | |
| 80 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5845 mL | |
| 100 mM | 0.0187 mL | 0.0935 mL | 0.1870 mL | 0.4676 mL |
UPGL00004 関連分類
HY-119377 関連分類
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