VE-465
VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 639089-73-9
- 分子式: C22H28N8OS
- 分子量:452.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Aurora Kinase アイソフォーム固有の製品をすべて表示
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
0.024 μM
Compound: 20
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Antiproliferative activity against human COLO205 cells assessed as inhibition of thymidine uptake after 96 hrs
Antiproliferative activity against human COLO205 cells assessed as inhibition of thymidine uptake after 96 hrs
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[PMID: 19320489] |
| COLO 205 | IC50 |
0.024 μM
Compound: 40
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Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake assay
Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake assay
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[PMID: 19447622] |
化学情報
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CAS 番号 639089-73-9
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分子量 452.58
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分子式 C22H28N8OS
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SMILES
CCC(NC1=CC=C(C=C1)SC2=NC(NC3=NNC(C)=C3)=CC(N4CCN(CC4)C)=N2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50(3):518-27. [Content Brief]
[2]. Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49(3):559-69. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VE-465 関連分類
HY-123697 関連分類
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