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製品番号: HY-N1065

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Xanthoxyletin

Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 84-99-1
分子式: C₁₅H₁₄O₄
分子量:258.27

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Xanthoxyletin 構造式

CAS 番号: 84-99-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	133.12 μM Compound: 8	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 21302964]
NCI-H187	IC₅₀	>200 μM Compound: 8	Cytotoxicity against human NCI-H187 by resazurin microplate assay Cytotoxicity against human NCI-H187 by resazurin microplate assay	[PMID: 21302964]
Vero	IC₅₀	>200 μM Compound: 8	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 21302964]

体外実験

Xanthoxyletin (1-500 µM; 30 min) inhibits DPPH radical with IC₅₀ values of 247.1 μM and 63.8 μg/mL, and also shows a ferric reducing antioxidant power (FRAP) value of 45.2 µM^[2].
Xanthoxyletin (10-500 µM; 24 h) shows cytotoxicity against HepG2, HCT116 and SK-LU-1 cancer cells with IC₅₀ values of 78.2, 79.8 and 94.4 μM, respectively^[2].
Xanthoxyletin (78 and 156 μM; 12 and 24 h) induces cell apoptosis and causes low necrosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

HepG2, HCT116, SK-LU-1 and Vero cell lines
Concentration:

10-500 µM
Incubation Time:

24 hours
Result:

Exhibited cytotoxicity to HepG2, HCT116 and SK-LU-1, but showed inactive effect to Vero cells.

Apoptosis Analysis^[2]

Cell Line:

HepG2 cell line^[2]
Concentration:

78 and 156 μM
Incubation Time:

12 and 24 hours
Result:

Induced apoptosis percentage of 49.6% and 64.2% at the dose of 78 and 156 μM, respectively. Showed a better apoptosis inducing effect that cisplatin.

化学情報

CAS 番号 84-99-1
分子量 258.27
分子式 C₁₅H₁₄O₄
SMILES

O=C(O1)C=CC(C1=C2)=C(OC)C3=C2OC(C)(C)C=C3
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859. [Content Brief]

[2]. Jantamat P, et al. Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena harmandiana. Molecules. 2019 Sep 18;24(18):3385.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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