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製品番号: HY-120264

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YPC-22026

YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC₅₀ value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities.

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CAS 番号: 1964457-41-7
分子式: C₁₆H₈F₃N₃O₂
分子量:331.25

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

YPC-22026 構造式

CAS 番号: 1964457-41-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC₅₀ value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities^[1].

体外実験

YPC‐22026 (96 h) shows cytotoxic to HCT116 and PC‐3 with IC₅₀ values of 0.33 μM and 0.66 μM, respectively^[1].
YPC‐22026 (3 μM; 24 h) induces G2/M arrest and decreases the binding of ZNF143 to the STAF binding site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

3 μM
Incubation Time:

24 h
Result:

Induced G2/M arrest.

体内実験

YPC‐22026 (50-100 mg/kg; i.p; on days 1, 2, 3, 8, 9, 12, and 16) significantly inhibits the growth of tumors in the HCT116 xenograft model^[1].
In the PC‐3 xenograft model, YPC‐22026 (75 mg/kg; ip) significantly decreases in the intratumoral expression levels of all ZNF143 target genes, RAD51, PLK1, and Survivin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six‐week‐old male BALB/c nude mice injected with HCT116 cells^[1]
Dosage:

50 mg/kg and 100 mg/kg
Administration:

i.p; on days 1, 2, 3, 8, 9, 12, and 16 (50 mg/kg ); on days 1, 2, 3, 12, and 16 (100 mg/kg)
Result:

Significantly inhibited the growth of tumors.

化学情報

CAS 番号 1964457-41-7
分子量 331.25
分子式 C₁₆H₈F₃N₃O₂
SMILES

FC(F)(F)OC1=CC=CC=C1C2=NN=C(C#CC3=CC=CN=C3)O2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hirotaka Haibara, et al. YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo. Cancer Sci. 2017 May;108(5):1042-1048. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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