ZV05

ZV05 (0.051-3000 ng/mL; 2 h) binds to the purified extracellular domain protein of h5T4, with an EC₅₀ of 4.3 ng/mL^[1].
ZV05 (0.01-10 μg/mL; 30 min on ice) specifically binds to the 5T4-positive cancer cell lines MDA-MB-468, DU 145 and BxPC-3, but does not bind to the 5T4-negative HepG2 or Ramos cell lines^[1].
ZV05 (multiple concentrations; 72 h) shows no cytotoxicity against the 5T4-positive cancer cell lines MDA-MB-468, DU 145, BxPC-3, Lovo, as well as the 5T4-negative human cancer cell line HepG2 following 72 h of incubation^[1].
ZV05 (0.139-10 μg/mL; 72 h) does not induce apoptosis in 5T4-positive MDA-MB-468 and DU 145 cancer cell lines even at concentrations up to 10 μg/mL after 72 h of incubation^[1].
ZV05 (0.139-10 μg/mL; 72 h) does not interfere with cell cycle progression or induce G₂/M phase arrest in the 5T4-positive human cancer cell lines MDA-MB-468 and DU 145, even at concentrations up to 10 μg/mL following a 72 h incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.