Junceellolide C 

Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC₅₀ values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent^[1].

EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells^[1]

Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC₅₀ values of 2.27, 3.52 μM, respectively^[1].
Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

540.99

C₂₆H₃₃ClO₁₀

121769-82-2

C[C@@]12[C@]([C@@H]([C@]3([C@@]([C@H](C(/C=C\[C@@H]2OC(C)=O)=C)Cl)([H])OC([C@@H]3C)=O)O)OC(C)=O)([H])[C@]4(CC[C@@H]1OC(C)=O)CO4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jiru Wu, et al. Briarane-type diterpenoids from a gorgonian coral Ellisella sp. with anti-HBV activities. Bioorg Chem. 2020 Dec;105:104423.  [Content Brief]