2. JAK/STAT Signaling
  3. Pim
  4. K00135

K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets.

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K00135 Chemical Structure

K00135 Chemical Structure

CAS No. : 869650-21-5

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Description

K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets[1].

Molecular Weight

306.36

Formula

C18H18N4O
CAS No.
SMILES

CC(C1=CC=CC(C2=CN=C3C=CC(NCC4CC4)=NN32)=C1)=O
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Room temperature in continental US; may vary elsewhere.
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K00135 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K00135869650-21-5K 00135K-00135PimPim kinasesAntileukemicPIM kinasesacute myelogenous leukemiaAMLInhibitorinhibitorinhibit

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HY-123141
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