K00135
Based on 1 Customer Validation
K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets.
For research use only. We do not sell to patients.
- Purity: 98.03%
- CAS No.: 869650-21-5
- Formula: C18H18N4O
- Molecular Weight:306.36
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
8 μM
Compound: K00135
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Growth inhibition of human K562 cells after 48 hrs by WST-1 assay
Growth inhibition of human K562 cells after 48 hrs by WST-1 assay
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[PMID: 22136433] |
| MOLM-13 | IC50 |
0.3 μM
Compound: K00135
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Growth inhibition of human MOLM13 cells after 48 hrs by WST-1 assay
Growth inhibition of human MOLM13 cells after 48 hrs by WST-1 assay
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[PMID: 22136433] |
| MV4-11 | IC50 |
0.4 μM
Compound: K00135
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Growth inhibition of human MV4-11 cells after 48 hrs by WST-1 assay
Growth inhibition of human MV4-11 cells after 48 hrs by WST-1 assay
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[PMID: 22136433] |
| RS4-11 | IC50 |
8.8 μM
Compound: K00135
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Growth inhibition of human RS4:11 cells after 48 hrs by WST-1 assay
Growth inhibition of human RS4:11 cells after 48 hrs by WST-1 assay
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[PMID: 22136433] |
| SEM | IC50 |
6 μM
Compound: K00135
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Growth inhibition of human SEM cells after 48 hrs by WST-1 assay
Growth inhibition of human SEM cells after 48 hrs by WST-1 assay
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[PMID: 22136433] |
Chemical Information
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CAS No. 869650-21-5
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Appearance Solid
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Molecular Weight 306.36
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Formula C18H18N4O
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Color Light yellow to light brown
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SMILES
CC(C1=CC=CC(C2=CN=C3C=CC(NCC4CC4)=NN32)=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 11.67 mg/mL (38.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2641 mL | 16.3207 mL | 32.6413 mL | 81.6033 mL |
| 5 mM | 0.6528 mL | 3.2641 mL | 6.5283 mL | 16.3207 mL | |
| 10 mM | 0.3264 mL | 1.6321 mL | 3.2641 mL | 8.1603 mL | |
| 15 mM | 0.2176 mL | 1.0880 mL | 2.1761 mL | 5.4402 mL | |
| 20 mM | 0.1632 mL | 0.8160 mL | 1.6321 mL | 4.0802 mL | |
| 25 mM | 0.1306 mL | 0.6528 mL | 1.3057 mL | 3.2641 mL | |
| 30 mM | 0.1088 mL | 0.5440 mL | 1.0880 mL | 2.7201 mL |
K00135 Related Classifications
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