2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Kakkalide

Kakkalide is an isoflavone derived from the flowers of Pueraria lobata. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species (ROS)-associated inflammation.

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Kakkalide Chemical Structure

Kakkalide Chemical Structure

CAS No. : 58274-56-9

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10 mg USD 857 Get quote
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Based on 1 publication(s) in Google Scholar

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Description

Kakkalide is an isoflavone derived from the flowers of Pueraria lobata. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species (ROS)-associated inflammation[1].

Molecular Weight

608.54

Formula

C28H32O15
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(O)C(OC)=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO[C@H]4[C@@H]([C@H]([C@H](O)CO4)O)O)C=C2OC=C1C5=CC=C(OC)C=C5
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (82.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6433 mL 8.2164 mL 16.4328 mL
5 mM 0.3287 mL 1.6433 mL 3.2866 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6433 mL 8.2164 mL 16.4328 mL 41.0819 mL
5 mM 0.3287 mL 1.6433 mL 3.2866 mL 8.2164 mL
10 mM 0.1643 mL 0.8216 mL 1.6433 mL 4.1082 mL
15 mM 0.1096 mL 0.5478 mL 1.0955 mL 2.7388 mL
20 mM 0.0822 mL 0.4108 mL 0.8216 mL 2.0541 mL
25 mM 0.0657 mL 0.3287 mL 0.6573 mL 1.6433 mL
30 mM 0.0548 mL 0.2739 mL 0.5478 mL 1.3694 mL
40 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0270 mL
50 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.8216 mL
60 mM 0.0274 mL 0.1369 mL 0.2739 mL 0.6847 mL
80 mM 0.0205 mL 0.1027 mL 0.2054 mL 0.5135 mL
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Kakkalide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kakkalide58274-56-9Reactive Oxygen SpeciesInhibitorinhibitorinhibit

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