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Cat. No.: HY-139862

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Keap1-Nrf2-IN-3

Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein−protein interaction inhibitor, and with a K_d value of 2.5 nM for KEAP1 protein.

For research use only. We do not sell to patients.

CAS No.: 2095066-47-8
Formula: C₃₁H₃₄N₆O₃
Molecular Weight:538.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Keap1-Nrf2-IN-3 Chemical Structure

CAS No.: 2095066-47-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein−protein interaction inhibitor, and with a K_d value of 2.5 nM for KEAP1 protein.

Chemical Information

CAS No. 2095066-47-8
Molecular Weight 538.64
Formula C₃₁H₃₄N₆O₃
SMILES

O=C(C1=C([C@H]2[C@H](C3=CN(C)N=N3)C2)N(C4=CC=CC(C5=CC=CC(C(N6[C@H](CCC)CCCC6)=O)=C5)=C4)N=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Norton D, et al. Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64(21):15949-15972. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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