Gantenerumab
Based on 1 Customer Validation
Gantenerumab is a fully humanized anti-Aβ IgG1 monoclonal antibody. Gantenerumab can specifically bind to Aβ fibrils and plaques and can be used in Alzheimer's disease research.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 1043556-46-2
- Molecular Weight:146.28 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
Amyloid Beta/Aβ
Gantenerumab (0.07-7 nM; 40-72 h) can reduce the Aβ plaque load in a concentration-dependent manner in the co-culture system of brain tissue sections from AD patients and primary human macrophages or microglia, and with an EC50 of approximately 0.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PS2APP transgenic mice by administering a single anti-CD4 injection[1]
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Dosage:20 mg/kg
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Administration:Intravenous injection; once a week; 5 months
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Result:Reduced the number of Aβ amyloid plaques in PS2APP mice compared with vehicle controls. Specifically, in the hippocampus, neocortex, and thalamus, the plaque numbers were significantly reduced by 36%, 40%, and 70% respectively.
Efficiently reduced the number of smaller plaques.
Did not cause neurological or locomotor deficits.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Loaded Gantenerumab on AHC2 biosensor, can bind Amyloid Precursor/Beta-APP42 Protein, Human (His-GST, HY-P76168) with an affinity constant of 5.257E-11 M as determined in BLI assay. -
Flow cytometric analysis of 1.5×106 HUVEC cells with Gantenerumab (HY-P99022, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control.
Chemical Information
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CAS No. 1043556-46-2
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Appearance Liquid
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Molecular Weight 146.28 kDa
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Color Colorless to light yellow
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SMILES
[Gantenerumab]
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Synonyms
R-04909832; RG-1450
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)