TNFSF13 - TNF superfamily member 13 Gene

Also Known as APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8741

About TNFSF13

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,558,282-7,561,601 (from NCBI)

This gene has 9 transcripts (splice variants), 97 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 37.5), gall bladder (RPKM 25.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF Receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce Apoptosis through its interaction with other TNF Receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF13 Products (6)

mRNA Protein Name
NM_001198622.2 NP_001185551.1 tumor necrosis factor ligand superfamily member 13 isoform delta
NM_001198623.2 NP_001185552.1 tumor necrosis factor ligand superfamily member 13 isoform zeta
NM_001198624.2 NP_001185553.1 tumor necrosis factor ligand superfamily member 13 isoform eta
NM_003808.4 NP_003799.1 tumor necrosis factor ligand superfamily member 13 isoform alpha precursor
NM_172087.3 NP_742084.1 tumor necrosis factor ligand superfamily member 13 isoform beta precursor
NM_172088.4 NP_742085.1 tumor necrosis factor ligand superfamily member 13 isoform gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of isotype switching to IgA isotypes IDA
IDA: Inferred from direct assay
14988498 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19828625 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFSF13 Protein Structure

TNF

TNF: TNF(Tumour Necrosis Factor) family (147 - 250)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 13

  • TNF- and APOL-related leukocyte expressed ligand 2

Recombinant TNFSF13 Proteins

Cat. No. Product Name Accession Purity
HY-P70733 APRIL/TNFSF13 Trimer Protein, Human (HEK293, Flag-His) O75888 (K112-L250) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700016AF Animal-Free APRIL/TNFSF13 Protein, Human (His) O75888 (A105-L250) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700661 APRIL/TNFSF13 Trimer Protein, Human (Biotinylated, HEK293, Flag, His-Avi) O75888-1 (K112-L250) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Common Variable Immunodeficiency

  • Cvid

  • Common Variable Agammaglobulinemia

  • Common Variable Immune Deficiency

  • Acquired Hypogammaglobulinemia

  • Hypogamma-Globulinemia, Acquired

  • Idiopathic Immunoglobulin Deficiency

  • Primary Antibody Deficiency

  • Primary Hypogammaglobulinemia

  • Acquired Agammaglobulinemia

  • Sporadic Hypogammaglobulinemia

  • Common Variable Hypogamma-Globulinemia

  • Immunoglobulin Deficiency, Late-Onset

  • Common Variable Hypogammaglobulinemia

  • Immunodeficiency, Common Variable
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Connective Tissue Disease

  • Connective Tissue Diseases

  • Connective Tissue Disorder

  • Abnormality Of Connective Tissue

  • Disorder Of Connective Tissue

  • Connective Tissue Disorders
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990070 Zigakibart Inhibitor 99.30% Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14823 TNFSF13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14824 TNFSF13B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17086 Tnfsf13b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17239 Tnfsf13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23530 Tnfsf13b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23693 Tnfsf13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992101 Aritinercept Inhibitor 99.9% Unkown
HY-P992479 UBP1213 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TNFSF13 VGNC VGNC:55879
Canis familiaris TNFSF13 VGNC VGNC:97225
Mus musculus TNFSF13 MGD MGI:1916833
Rattus norvegicus TNFSF13 RGD RGD:1305871
Others TNFSF13 NCBI