KB05yne
Based on 1 Customer Validation
KB05yne is a site-selective, alkyne-functionalized electrophilic "probe" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1) but does not label their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for the discovery and optimization of site-specific covalent ligands, and is applicable to proteins with diverse structures and functions, especially in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 2724919-69-9
- Formula: C22H21BrN2O2
- Molecular Weight:425.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
KB05yne exhibits preferential reactivity toward specific cysteine residues in proteins, and strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2724919-69-9
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Appearance Oil
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Molecular Weight 425.32
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Formula C22H21BrN2O2
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Color Colorless to light yellow
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SMILES
O=C(NCCCCC#C)C1=CC=C(N(C2=CC=C(Br)C=C2)C(C=C)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 100 mg/mL (235.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3512 mL | 11.7559 mL | 23.5117 mL | 58.7793 mL |
| 5 mM | 0.4702 mL | 2.3512 mL | 4.7023 mL | 11.7559 mL | |
| 10 mM | 0.2351 mL | 1.1756 mL | 2.3512 mL | 5.8779 mL | |
| 15 mM | 0.1567 mL | 0.7837 mL | 1.5674 mL | 3.9186 mL | |
| 20 mM | 0.1176 mL | 0.5878 mL | 1.1756 mL | 2.9390 mL | |
| 25 mM | 0.0940 mL | 0.4702 mL | 0.9405 mL | 2.3512 mL | |
| 30 mM | 0.0784 mL | 0.3919 mL | 0.7837 mL | 1.9593 mL | |
| 40 mM | 0.0588 mL | 0.2939 mL | 0.5878 mL | 1.4695 mL | |
| 50 mM | 0.0470 mL | 0.2351 mL | 0.4702 mL | 1.1756 mL | |
| 60 mM | 0.0392 mL | 0.1959 mL | 0.3919 mL | 0.9797 mL | |
| 80 mM | 0.0294 mL | 0.1469 mL | 0.2939 mL | 0.7347 mL | |
| 100 mM | 0.0235 mL | 0.1176 mL | 0.2351 mL | 0.5878 mL |
KB05yne Related Classifications
HY-177554 Related Classifications
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