Sabirnetug
Based on 1 Customer Validation
Sabirnetug (ACU-193) is a blood-brain barrier-penetrant monoclonal antibody that selectively targets AβO and binds to soluble amyloid β oligomers. Sabirnetug can be used for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity : 96.84%
- CAS No.: 2747959-38-0
- Molecular Weight:144.78 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity
Human
|
ADDLs 0.319 nM (Kd) |
β-amyloid oligomers 17 nM (IC50) |
AβO 9 nM (IC50) |
In Vitro
Sabirnetug (ACU-193) is a humanized, affinity-matured IgG2 antibody that selectively binds soluble β-amyloid oligomers with low nanomolar affinity[2].
Sabirnetug blocks the synaptic binding of soluble β-amyloid oligomers in cultured hippocampal neurons with an IC50 of 17 nM, even in the presence of excess β-amyloid monomers[2].
Sabirnetug (ACU-193) (AβO IC50 = 9 nM; Aβ40 monomer IC50 = 5 µM) preferentially binds AβOs over Aβ40 monomers in a competitive ELISA[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG2 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized β-Amyloid (42-1), human (HY-P1362) can bind Sabirnetug. The EC50 for this effect is 42.33 ng/mL. -
Flow cytometric analysis of 1X106 HUVEC cells with Sabirnetug (HY-P990011, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2747959-38-0
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Appearance Liquid
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Molecular Weight 144.78 kDa
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Color Colorless to light yellow
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SMILES
[Sabirnetug]
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Synonyms
ACU-193
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)