2′-Thioadenosine
2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 136904-69-3
- 화학식: C10H13N5O3S
- 분자량:283.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Biological Activity
제품 설명
IC50 & Target
[1]|
ErbB1 |
ErbB2 45 μM (IC50) |
In Vitro
2'-Thioadenosine (50 µM) exhibits no activity against FGF, PDGF orinsulin receptor tyrosine kinases[1].
2'-Thioadenosine covalently inactivates ErbB-1, which is reversed by 1 mM Dithiothreitol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 136904-69-3
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분자량 283.31
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화학식 C10H13N5O3S
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SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1
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Synonyms
PD157432
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2′-Thioadenosine Related Classifications
HY-137028 Related Classifications
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