2′-Thioadenosine
2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 136904-69-3
- 화학식: C10H13N5O3S
- 분자량:283.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Biological Activity
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ErbB1 |
ErbB2 45 μM (IC50) |
2'-Thioadenosine (50 µM) exhibits no activity against FGF, PDGF orinsulin receptor tyrosine kinases[1].
2'-Thioadenosine covalently inactivates ErbB-1, which is reversed by 1 mM Dithiothreitol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 136904-69-3
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분자량 283.31
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화학식 C10H13N5O3S
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SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1
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Synonyms
PD157432
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2′-Thioadenosine Related Classifications
HY-137028 Related Classifications
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