Afegostat
Based on 1 Customer Validation
Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.
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- Purity: 99.83%
- CAS No.: 169105-89-9
- 화학식: C6H13NO3
- 분자량:147.17
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보관:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
GCase[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
2 μM
Compound: 7, D-IFG
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Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
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[PMID: 18595718] |
| Hepatocyte | IC50 |
2 μM
Compound: 9
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Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
Inhibition of glucagon-stimulated glycogen degradation in hepatocytes
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[PMID: 16970395] |
| Hepatocyte | IC50 |
3 μM
Compound: 7, D-IFG
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Inhibition of basal glycogen degradation in hepatocytes
Inhibition of basal glycogen degradation in hepatocytes
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[PMID: 18595718] |
| Hepatocyte | IC50 |
3 μM
Compound: 9
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Inhibition of glycogen degradation in hepatocytes
Inhibition of glycogen degradation in hepatocytes
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[PMID: 16970395] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 169105-89-9
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Appearance Oil
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분자량 147.17
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화학식 C6H13NO3
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Color Colorless to light yellow
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SMILES
O[C@@H]1CNC[C@H](CO)[C@H]1O
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Synonyms
D-Isofagomine; Isofagomine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
H2O : 4.17 mg/mL (28.33 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.7949 mL | 33.9743 mL | 67.9486 mL | 169.8716 mL |
| 5 mM | 1.3590 mL | 6.7949 mL | 13.5897 mL | 33.9743 mL | |
| 10 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL | 16.9872 mL | |
| 15 mM | 0.4530 mL | 2.2650 mL | 4.5299 mL | 11.3248 mL | |
| 20 mM | 0.3397 mL | 1.6987 mL | 3.3974 mL | 8.4936 mL | |
| 25 mM | 0.2718 mL | 1.3590 mL | 2.7179 mL | 6.7949 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Afegostat Related Classifications
HY-14829 Related Classifications
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